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Cited by 94Drug Transport and Resistance MechanismsProtein Structure and DynamicsAmino Acid Enzymes and Metabolism

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Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes

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Killer, Maxime, Wald, Jiri, Pieprzyk, Joanna, Marlovits, Thomas C., Löw, Christian·2021·Science Advances
DOI 10.1126/sciadv.abk3259PMC PMC8565842

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Abstract

Structures of PepT1 and PepT2 provide mechanistic insights into substrate and drug translocation across epithelial membranes.

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Metadata

Authors
Killer, M., Wald, J., Pieprzyk, J., Marlovits, T. C., & Löw, C.
Affiliations
  • Heidelberg University (DE)
  • Deutsches Elektronen-Synchrotron DESY (DE)
Corresponding author
Löw, Christian
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-11-05
Volume
7
Issue
45
Pages
eabk3259-eabk3259
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abk3259
PMC
PMC8565842
OpenAlex
W3210360742
Cited by
94
References
2
Citations by year
2026: 19 · 2025: 15 · 2024: 26 · 2023: 20 · 2022: 14
FWCI
5.46
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science Advances (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
PepT1, PEPT2, peptide transporters, major facilitator superfamily, transporter structure, transport mechanisms, substrate recognition, conformational change, drug transport, intestinal drug absorption, bioavailability, cryo-EM structure

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