The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors
Open accessAbstract
Adoptive cell therapy (ACT) has proven to be highly effective in treating blood cancers, but traditional approaches to ACT are poorly effective in treating solid tumors observed clinically. Novel delivery methods for therapeutic cells have shown promise for treatment of solid tumors when compared with standard intravenous administration methods, but the few reported approaches leverage biomaterials that are complex to manufacture and have primarily demonstrated applicability following tumor resection or in immune-privileged tissues. Here, we engineer simple-to-implement injectable hydrogels for the controlled co-delivery of CAR-T cells and stimulatory cytokines that improve treatment of solid tumors. The unique architecture of this material simultaneously inhibits passive diffusion of entrapped cytokines and permits active motility of entrapped cells to enable long-term retention, viability, and activation of CAR-T cells. The generation of a transient inflammatory niche following administration affords sustained exposure of CAR-T cells, induces a tumor-reactive CAR-T phenotype, and improves efficacy of treatment.
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Self-citationEngineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
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Translational Applications of Hydrogels
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Self-citationCo-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
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Cited by
Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Injectable hydrogels as emerging drug-delivery platforms for tumor therapy
Cheng, Y., Zhang, H., Wei, H., & Yu, C.-Y. (2024) · Biomaterials Science · doi:10.1039/d3bm01840g · Cited by 65
Biomaterial-driven 3D scaffolds for immune cell expansion toward personalized immunotherapy
Minopoli, A., Perini, G., Cui, L., Palmieri, V., De Spirito, M., & Papi, M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.05.027 · Cited by 19
Metadata
- Authors
- Grosskopf, A. K., Labanieh, L., Klysz, D. D., Roth, G. A., Xu, P., Adebowale, O., Gale, E. C., Jons, C. K., Klich, J. H., Yan, J., Maikawa, C. L., Correa, S., Ou, B. S., d’Aquino, A. I., Cochran, J. R., Chaudhuri, O., Mackall, C. L., & Appel, E. A.
- Venue
- Science Advances
- Published
- 2022-04-08
- Volume
- 8
- Issue
- 14
- Pages
- eabn8264-eabn8264
- ISSN
- 2375-2548 (ISSN-L)
- OpenAlex
- W4226203376
- Cited by
- 253
- References
- 51
- FWCI
- 18.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Grosskopf, A. K., Labanieh, L., Klysz, D. D., Roth, G. A., Xu, P., Adebowale, O., Gale, E. C., Jons, C. K., Klich, J. H., Yan, J., Maikawa, C. L., Correa, S., Ou, B. S., d’Aquino, A. I., Cochran, J. R., Chaudhuri, O., Mackall, C. L., & Appel, E. A. (2022). Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors. Science Advances. https://doi.org/10.1126/sciadv.abn8264
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
