The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction
Abstract
Several phospholipase C (PLC) isoforms have been found in male and female mammalian gametes, and splicing isoforms of PLCδ4 are predominantly expressed in testis. Here we report that male mice in which the PLCδ4 gene had been disrupted either produced few small litters or were sterile. In vitro fertilization studies showed that insemination with PLCδ4 −/− sperm resulted in significantly fewer eggs becoming activated and that the calcium transients associated with fertilization were absent or delayed. PLCδ4 −/− sperm were unable to initiate the acrosome reaction, an exocytotic event required for fertilization and induced by interaction with the egg coat, the zona pellucida. These data demonstrate that PLCδ4 functions in the acrosome reaction that is induced by the zona pellucida during mammalian fertilization.
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Citations
Cites
Regulation of Phosphoinositide-specific Phospholipase C Isozymes
Rhee, S. G., & Bae, Y. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15045 · Cited by 876
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077544 · Cited by 1,153
PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development
Saunders, C. M., Larman, M. G., Parrington, J., Cox, L. J., Royse, J., Blayney, L. M., Swann, K., & Lai, F. A. (2002) · Development · doi:10.1242/dev.129.15.3533 · Cited by 1,010
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.415 · Cited by 501
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Metadata
- Authors
- Fukami, K., Nakao, K., Inoue, T., Kataoka, Y., Kurokawa, M., Fissore, R. A., Nakamura, K., Katsuki, M., Mikoshiba, K., Yoshida, N., & Takenawa, T.
- Venue
- Science
- Published
- 2001-05-04
- Volume
- 292
- Issue
- 5518
- Pages
- 920-923
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2103609214
- Cited by
- 207
- References
- 1
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fukami, K., Nakao, K., Inoue, T., Kataoka, Y., Kurokawa, M., Fissore, R. A., Nakamura, K., Katsuki, M., Mikoshiba, K., Yoshida, N., & Takenawa, T. (2001). Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction. Science. https://doi.org/10.1126/science.1059042
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