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PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development
Abstract
Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca2+ oscillations that are essential for embryo development. The mechanism by which sperm induces this complex signalling phenomenon is unknown. One proposal is that the sperm introduces an exclusive cytosolic factor into the egg that elicits serial Ca2+ release. The ‘sperm factor’ hypothesis has not been ratified because a sperm-specific protein that generates repetitive Ca2+ transients and egg activation has not been found. We identify a novel, sperm-specific phospholipase C, PLCζ, that triggers Ca2+ oscillations in mouse eggs indistinguishable from those at fertilisation. PLCζ removal from sperm extracts abolishes Ca2+ release in eggs. Moreover, the PLCζ content of a single sperm was sufficient to produce Ca2+ oscillations as well as normal embryo development to blastocyst. Our results are consistent with sperm PLCζ as the molecular trigger for development of a fertilised egg into an embryo.
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Citations
Cites
The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701
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Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Kadamur, G., & Ross, E. M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183750 · Cited by 529
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.415 · Cited by 501
Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age
Jones, K. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmm043 · Cited by 228
Metadata
- Authors
- Saunders, C. M., Larman, M. G., Parrington, J., Cox, L. J., Royse, J., Blayney, L. M., Swann, K., & Lai, F. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-08-01
- Volume
- 129
- Issue
- 15
- Pages
- 3533-3544
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2097939257
- Cited by
- 1,010
- References
- 1
- FWCI
- 45.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saunders, C. M., Larman, M. G., Parrington, J., Cox, L. J., Royse, J., Blayney, L. M., Swann, K., & Lai, F. A. (2002). PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development. Development. https://doi.org/10.1242/dev.129.15.3533
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