The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chemical Glycobiology
Abstract
Chemical tools have proven indispensable for studies in glycobiology. Synthetic oligosaccharides and glycoconjugates provide materials for correlating structure with function. Synthetic mimics of the complex assemblies found on cell surfaces can modulate cellular interactions and are under development as therapeutic agents. Small molecule inhibitors of carbohydrate biosynthetic and processing enzymes can block the assembly of specific oligosaccharide structures. Inhibitors of carbohydrate recognition and biosynthesis can reveal the biological functions of the carbohydrate epitope and its cognate receptors. Carbohydrate biosynthetic pathways are often amenable to interception with synthetic unnatural substrates. Such metabolic interference can block the expression of oligosaccharides or alter the structures of the sugars presented on cells. Collectively, these chemical approaches are contributing great insight into the myriad biological functions of oligosaccharides.
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Cites
Rational design of potent sialidase-based inhibitors of influenza virus replication
von Itzstein, M., Wu, W.-Y., Kok, G. B., Pegg, M. S., Dyason, J. C., Jin, B., Van Phan, T., Smythe, M. L., White, H. F., Oliver, S. W., et al. (1993) · Nature · doi:10.1038/363418a0 · Cited by 1,862
Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
Ladmiral, V., Mantovani, G., Clarkson, G. J., Cauet, S., Irwin, J. L., & Haddleton, D. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058364k · Cited by 586
Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands
Cecioni, S., Imberty, A., & Vidal, S. (2015) · Chemical Reviews · doi:10.1021/cr500303t · Cited by 544
Structural Investigations of Glycoconjugates at High Sensitivity
Mechref, Y., & Novotny, M. V. (2002) · Chemical Reviews · doi:10.1021/cr0103017 · Cited by 341
Percec, V., Leowanawat, P., Sun, H.-J., Kulikov, O., Nusbaum, C. D., Tran, T. M., Bertin, A., Wilson, D. A., Peterca, M., Zhang, S., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja403323y · Cited by 310
Metadata
- Authors
- Bertozzi, C. R., & Kiessling, A. L. L.
- Venue
- Science
- Published
- 2001-03-23
- Volume
- 291
- Issue
- 5512
- Pages
- 2357-2364
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4251775387
- Cited by
- 1,939
- References
- 1
- FWCI
- 41.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
