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Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
Abstract
Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)–containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.
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Citations
Cited by
Lanier, L. L. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,769
Defining trained immunity and its role in health and disease
Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., et al. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0285-6 · Cited by 2,690
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1864 · Cited by 1,331
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
Beutler, B., Jiang, Z., Georgel, P., Crozat, K., Croker, B., Rutschmann, S., Du, X., & Hoebe, K. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090552 · Cited by 772
Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610
Metadata
- Authors
- Brown, M. G., Dokun, A. O., Heusel, J. W., Smith, H. R. C., Beckman, D. L., Blattenberger, E. A., Dubbelde, C. E., Stone, L. R., Scalzo, A. A., & Yokoyama, W. M.
- Venue
- Science
- Published
- 2001-05-04
- Volume
- 292
- Issue
- 5518
- Pages
- 934-937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095548329
- Cited by
- 627
- References
- 0
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection. https://app.cochat.ai/papers/10.1126/science.1060042
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- Brown, M. G., Dokun, A. O., Heusel, J. W., Smith, H. R. C., Beckman, D. L., Blattenberger, E. A., Dubbelde, C. E., Stone, L. R., Scalzo, A. A., & Yokoyama, W. M. (2001). Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection. Science. https://doi.org/10.1126/science.1060042
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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