The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Cholesterol Quartet
Abstract
A high cholesterol diet is known to promote the formation of atherosclerotic plaques in arteries, leading to coronary heart disease. However, there are four monogenic diseases in which plasma cholesterol increases independently of diet due to defects in liver LDL receptors, which fail to clear cholesterol-carrying LDLs from plasma. In a lively and informative Perspective, Brown and Goldstein discuss the newest member of the cholesterol disease quartet, autosomal recessive hypercholesterolemia (ARH), and speculate how mutations in the ARH protein could lead to defective functioning of liver LDL receptors.
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Citations
Cites
Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., & Herz, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000955200 · Cited by 450
Cited by
Genomewide Association Studies and Human Disease
Hardy, J., & Singleton, A. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808700 · Cited by 733
Genetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia: A HuGE Prevalence Review
Austin, M. A. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh236 · Cited by 657
Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
Civeira, F. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.11.010 · Cited by 495
Nabel, E. G. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035098 · Cited by 431
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
Cunningham, D., Danley, D. E., Geoghegan, K. F., Griffor, M. C., Hawkins, J. L., Subashi, T. A., Varghese, A. H., Ammirati, M. J., Culp, J. S., Hoth, L. R., et al. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1235 · Cited by 409
Metadata
- Authors
- Goldstein, J. L., & Brown, M. S.
- Venue
- Science
- Published
- 2001-05-18
- Volume
- 292
- Issue
- 5520
- Pages
- 1310-1312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970346631
- Cited by
- 241
- References
- 1
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
