Cited by 1,884Advanced Biosensing Techniques and ApplicationsAdvanced Proteomics Techniques and ApplicationsFungal and yeast genetics research

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Global Analysis of Protein Activities Using Proteome Chips

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Zhu, Heng, Bilgin, Metin, Bangham, Rhonda, Hall, David, Casamayor, Antonio, Bertone, Paul, Lan, Ning, Jansen, Ronald, Bidlingmaier, Scott, Houfek, Thomas, Mitchell, Tom, Miller, Perry, Dean, Ralph A., Gerstein, Mark, Snyder, Michael·2001·Science

DOI 10.1126/science.1062191

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Abstract

To facilitate studies of the yeast proteome, we cloned 5800 open reading frames and overexpressed and purified their corresponding proteins. The proteins were printed onto slides at high spatial density to form a yeast proteome microarray and screened for their ability to interact with proteins and phospholipids. We identified many new calmodulin- and phospholipid-interacting proteins; a common potential binding motif was identified for many of the calmodulin-binding proteins. Thus, microarrays of an entire eukaryotic proteome can be prepared and screened for diverse biochemical activities. The microarrays can also be used to screen protein-drug interactions and to detect posttranslational modifications.

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For details of 96-well format protein purification protocol a full list of results from all the experiments and the design of the positive identification algorithms please visit our public Web site () and supplementary material at Science Online (www.sciencemag.org/cgi/content/full/1062191/DC1).
10.1016/S1567-1356(01)00005-8 · DOI
Positives were identified using a combination of the GenePix software which computes a local intensity background for each spot and a series of algorithms we developed. Details can be found at and at www.sciencemag.org/cgi/content/full/1062191/DC1.

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Authors: Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Jansen, R., Bidlingmaier, S., Houfek, T., Mitchell, T., Miller, P., Dean, R. A., Gerstein, M., & Snyder, M.
Affiliations: Department of Molecular, Cellular, and Developmental Biology and
Yale University (US)
North Carolina State University (US)
Corresponding author: Snyder, Michael
ORCID: Zhu, Heng
Casamayor, Antonio
Bertone, Paul
Lan, Ning
Bidlingmaier, Scott
Dean, Ralph A.
Gerstein, Mark
Snyder, Michael
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2001-09-14
Volume: 293
Issue: 5537
Pages: 2101-2105
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1062191
OpenAlex: W4233751197
Cited by: 1,884
References: 37
Citations by year: 2026: 9 · 2025: 16 · 2024: 20 · 2023: 23 · 2022: 37 · 2021: 35 · 2020: 34 · 2019: 33 · 2018: 39 · 2017: 49 · 2016: 56 · 2015: 62 · 2014: 61 · 2013: 60 · 2012: 97
FWCI: 47.46
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: proteome microarray, yeast proteome, protein-protein interaction, phospholipid binding, calmodulin-binding proteins, calmodulin binding motif, drug-protein interactions, post-translational modification
MeSH terms: Amino Acid Sequence, Calmodulin, Calmodulin-Binding Proteins, Cell Membrane, Cloning, Molecular, Fungal Proteins, Glucose, Liposomes, Membrane Proteins, Molecular Sequence Data, Phosphatidylcholines, Phosphatidylinositols, Phospholipids, Protein Binding, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Signal Transduction, Open Reading Frames, Peptide Library, Streptavidin, Proteome, Amino Acid Motifs

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Global Analysis of Protein Activities Using Proteome Chips

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