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Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
Abstract
Boron-doped silicon nanowires (SiNWs) were used to create highly sensitive, real-time electrically based sensors for biological and chemical species. Amine- and oxide-functionalized SiNWs exhibit pH-dependent conductance that was linear over a large dynamic range and could be understood in terms of the change in surface charge during protonation and deprotonation. Biotin-modified SiNWs were used to detect streptavidin down to at least a picomolar concentration range. In addition, antigen-functionalized SiNWs show reversible antibody binding and concentration-dependent detection in real time. Lastly, detection of the reversible binding of the metabolic indicator Ca 2+ was demonstrated. The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics.
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Cited by
One‐Dimensional Nanostructures: Synthesis, Characterization, and Applications
Xia, Y., Yang, P., Sun, Y., Wu, Y., Mayers, B., Gates, B., Yin, Y., Kim, F., & Yan, H. (2003) · Advanced Materials · doi:10.1002/adma.200390087 · Cited by 8,559
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Photoinduced Conversion of Silver Nanospheres to Nanoprisms
Jin, R., Cao, Y., Mirkin, C. A., Kelly, K. L., Schatz, G. C., & Zheng, J. G. (2001) · Science · doi:10.1126/science.1066541 · Cited by 3,384
Growth of nanowire superlattice structures for nanoscale photonics and electronics
Gudiksen, M. S., Lauhon, L. J., Wang, J., Smith, D. C., & Lieber, C. M. (2002) · Nature · doi:10.1038/415617a · Cited by 2,709
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Metadata
- Authors
- Cui, Y., Wei, Q., Park, H., & Lieber, C. M.
- Venue
- Science
- Published
- 2001-08-17
- Volume
- 293
- Issue
- 5533
- Pages
- 1289-1292
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987416224
- Cited by
- 5,809
- References
- 0
- FWCI
- 99.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cui, Y., Wei, Q., Park, H., & Lieber, C. M. (2001). Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species. Science. https://doi.org/10.1126/science.1062711
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