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Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses
Abstract
In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
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Cited by
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
de Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J. D., Chau, T. N. B., Hoang, D. M., Van Vinh Chau, N., Khanh, T. H., Dong, V. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1477 · Cited by 1,858
Imai, M., Watanabe, T., Hatta, M., Das, S. C., Ozawa, M., Shinya, K., Zhong, G., Hanson, A., Katsura, H., Watanabe, S., et al. (2012) · Nature · doi:10.1038/nature10831 · Cited by 1,523
Self-citationInfluenza virus receptors in the human airway
Shinya, K., Ebina, M., Yamada, S., Ono, M., Kasai, N., & Kawaoka, Y. (2006) · Nature · doi:10.1038/440435a · Cited by 1,398
Self-citationCharacterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Metadata
- Authors
- Hatta, M., Gao, P., Halfmann, P., & Kawaoka, Y.
- Venue
- Science
- Published
- 2001-09-07
- Volume
- 293
- Issue
- 5536
- Pages
- 1840-1842
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024970913
- Cited by
- 1,338
- References
- 0
- FWCI
- 23.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hatta, M., Gao, P., Halfmann, P., & Kawaoka, Y. (2001). Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses. Science. https://doi.org/10.1126/science.1062882
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
