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The Mitotic Spindle: A Self-Made Machine
Abstract
The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and other molecules. It assembles around the chromosomes and distributes the duplicated genome to the daughter cells during mitosis. The biochemical and physical principles that govern the assembly of this machine are still unclear. However, accumulated discoveries indicate that chromosomes play a key role. Apparently, they generate a local cytoplasmic state that supports the nucleation and growth of microtubules. Then soluble and chromosome-associated molecular motors sort them into a bipolar array. The emerging picture is that spindle assembly is governed by a combination of modular principles and that their relative contribution may vary in different cell types and in various organisms.
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Cited by
Aurora-A: the maker and breaker of spindle poles
Barr, A. R., & Gergely, F. (2007) · Journal of Cell Science · doi:10.1242/jcs.013136 · Cited by 441
Mechanisms for focusing mitotic spindle poles by minus end–directed motor proteins
Goshima, G., Nédélec, F., & Vale, R. D. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505107 · Cited by 259
Cai, S., Weaver, L. N., Ems-McClung, S. C., & Walczak, C. E. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-09-0971 · Cited by 189
Michel, L., Diaz-Rodriguez, E., Narayan, G., Hernando, E., Murty, V. V. V. S., & Benezra, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306069101 · Cited by 188
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity
Zhang, X., Ems-McClung, S. C., & Walczak, C. E. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0198 · Cited by 123
Metadata
- Authors
- Karsenti, E., & Vernos, I.
- Venue
- Science
- Published
- 2001-10-19
- Volume
- 294
- Issue
- 5542
- Pages
- 543-547
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037624113
- Cited by
- 456
- References
- 0
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
