The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Aurora-A: the maker and breaker of spindle poles
Open accessAbstract
The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although Aurora-A may not be a bona fide oncoprotein in humans, it is a promising drug target in cancer therapy. Thus, it is surprising that so little is known of its role in normal cells. The primary function of Aurora-A is to promote bipolar spindle assembly, but the molecular details of this process remained obscure until recently. The discovery of several novel Aurora-A-binding proteins and substrates has implicated Aurora-A in centrosome maturation and separation, acentrosomal and centrosomal spindle assembly, kinetochore function, cytokinesis and in cell fate determination. Here we discuss recent advances in determining the early mitotic role of Aurora-A, with a strong emphasis on its function at the mitotic spindle poles.
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Cites
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Cited by
Shared and separate functions of polo-like kinases and aurora kinases in cancer
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Aurora A kinase (AURKA) in normal and pathological cell division
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Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions
Hubner, N. C., Bird, A. W., Cox, J., Splettstoesser, B., Bandilla, P., Poser, I., Hyman, A., & Mann, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911091 · Cited by 440
The RanGTP gradient—a GPS for the mitotic spindle
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Metadata
- Authors
- Barr, A. R., & Gergely, F.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2007-09-01
- Volume
- 120
- Issue
- 17
- Pages
- 2987-2996
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1985338536
- Cited by
- 441
- References
- 118
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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