The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Synaptotagmin Modulation of Fusion Pore Kinetics in Regulated Exocytosis of Dense-Core Vesicles
Abstract
In the exocytosis of neurotransmitter, fusion pore opening represents the first instant of fluid contact between the vesicle lumen and extracellular space. The existence of the fusion pore has been established by electrical measurements, but its molecular composition is unknown. The possibility that synaptotagmin regulates fusion pores was investigated with amperometry to monitor exocytosis of single dense-core vesicles. Overexpression of synaptotagmin I prolonged the time from fusion pore opening to dilation, whereas synaptotagmin IV shortened this time. Both synaptotagmin isoforms reduced norepinephrine flux through open fusion pores. Thus, synaptotagmin interacts with fusion pores, possibly by associating with a core complex of membrane proteins and/or lipid.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Cited by
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
Chapman, E. R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm855 · Cited by 485
Self-citationElectrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364
Metadata
- Authors
- Wang, C.-T., Grishanin, R., Earles, C. A., Chang, P. Y., Martin, T. F. J., Chapman, E. R., & Jackson, M. B.
- Venue
- Science
- Published
- 2001-11-02
- Volume
- 294
- Issue
- 5544
- Pages
- 1111-1115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035070093
- Cited by
- 291
- References
- 2
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, C.-T., Grishanin, R., Earles, C. A., Chang, P. Y., Martin, T. F. J., Chapman, E. R., & Jackson, M. B. (2001). Synaptotagmin Modulation of Fusion Pore Kinetics in Regulated Exocytosis of Dense-Core Vesicles. Science. https://doi.org/10.1126/science.1064002
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