The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Requirement of Heterochromatin for Cohesion at Centromeres
Abstract
Centromeres are heterochromatic in many organisms, but the mitotic function of this silent chromatin remains unknown. During cell division, newly replicated sister chromatids must cohere until anaphase when Scc1/Rad21–mediated cohesion is destroyed. In metazoans, chromosome arm cohesins dissociate during prophase, leaving centromeres as the only linkage before anaphase. It is not known what distinguishes centromere cohesion from arm cohesion. Fission yeast Swi6 (a Heterochromatin protein 1 counterpart) is a component of silent heterochromatin. Here we show that this heterochromatin is specifically required for cohesion between sister centromeres. Swi6 is required for association of Rad21-cohesin with centromeres but not along chromosome arms and, thus, acts to distinguish centromere from arm cohesion. Therefore, one function of centromeric heterochromatin is to attract cohesin, thereby ensuring sister centromere cohesion and proper chromosome segregation.
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Cites
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Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
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Cited by
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Heterochromatin and Epigenetic Control of Gene Expression
Grewal, S. I. S., & Moazed, D. (2003) · Science · doi:10.1126/science.1086887 · Cited by 1,065
Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms
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Epigenetic inheritance in plants
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The molecular basis for centromere identity and function
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Metadata
- Authors
- Bernard, P., Maure, J.-F., Partridge, J. F., Genier, S., Javerzat, J.-P., & Allshire, R. C.
- Venue
- Science
- Published
- 2001-12-21
- Volume
- 294
- Issue
- 5551
- Pages
- 2539-2542
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070122527
- Cited by
- 616
- References
- 25
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bernard, P., Maure, J.-F., Partridge, J. F., Genier, S., Javerzat, J.-P., & Allshire, R. C. (2001). Requirement of Heterochromatin for Cohesion at Centromeres. Science. https://doi.org/10.1126/science.1064027
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
