The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus
Abstract
Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken β-globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the β-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin.
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Citations
Cites
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101
Self-citation
Cited by
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Gene Silencing in Cancer in Association with Promoter Hypermethylation
Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,422
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
Self-citationActive Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
Schultz, D. C., Ayyanathan, K., Negorev, D., Maul, G. G., & Rauscher, F. J. (2002) · Genes & Development · doi:10.1101/gad.973302 · Cited by 1,313
Metadata
- Authors
- Litt, M. D., Simpson, M., Gaszner, M., Allis, C. D., & Felsenfeld, G.
- Venue
- Science
- Published
- 2001-09-28
- Volume
- 293
- Issue
- 5539
- Pages
- 2453-2455
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974193054
- Cited by
- 580
- References
- 2
- FWCI
- 24.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Litt, M. D., Simpson, M., Gaszner, M., Allis, C. D., & Felsenfeld, G. (2001). Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus. Science. https://doi.org/10.1126/science.1064413
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