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RGS-PX1, a GAP for Gα s and Sorting Nexin in Vesicular Trafficking
Abstract
Heterotrimeric GTP–binding proteins (G proteins) control cellular functions by transducing signals from the outside to the inside of cells. Regulator of G protein signaling (RGS) proteins are key modulators of the amplitude and duration of G protein–mediated signaling through their ability to serve as guanosine triphosphatase–activating proteins (GAPs). We have identified RGS-PX1, a Gα s -specific GAP. The RGS domain of RGS-PX1 specifically interacted with Gα s , accelerated its GTP hydrolysis, and attenuated Gα s -mediated signaling. RGS-PX1 also contains a Phox (PX) domain that resembles those in sorting nexin (SNX) proteins. Expression of RGS-PX1 delayed lysosomal degradation of the EGF receptor. Because of its bifunctional role as both a GAP and a SNX, RGS-PX1 may link heterotrimeric G protein signaling and vesicular trafficking.
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Cites
Haft, C. R., de la Luz Sierra, M., Barr, V. A., Haft, D. H., & Taylor, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7278 · Cited by 244
Cited by
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,701
Systemic effects of chronic obstructive pulmonary disease
Agustí, A. G. N., Noguera, A., Sauleda, J., Sala, E., Pons, J., & Busquets, X. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00405703 · Cited by 1,045
Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling
Sunahara, R. K. (2002) · Molecular Interventions · doi:10.1124/mi.2.3.168 · Cited by 406
Endosomal sorting and signalling: an emerging role for sorting nexins
Cullen, P. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2427 · Cited by 404
Regulators of G-Protein signalling as new central nervous system drug targets
Neubig, R. R., & Siderovski, D. P. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd747 · Cited by 403
Metadata
- Authors
- Zheng, B., Ma, Y.-C., Ostrom, R. S., Lavoie, C., Gill, G. N., Insel, P. A., Huang, X.-Y., & Farquhar, M. G.
- Venue
- Science
- Published
- 2001-11-30
- Volume
- 294
- Issue
- 5548
- Pages
- 1939-1942
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061325944
- Cited by
- 236
- References
- 1
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zheng, B., Ma, Y.-C., Ostrom, R. S., Lavoie, C., Gill, G. N., Insel, P. A., Huang, X.-Y., & Farquhar, M. G. (2001). RGS-PX1, a GAP for Gα s and Sorting Nexin in Vesicular Trafficking. Science. https://doi.org/10.1126/science.1064757
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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