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Endosomal sorting and signalling: an emerging role for sorting nexins

Cullen, Peter J.·2008·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2427
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Abstract

The endocytic network comprises a series of interconnected tubulo-vesicular membranous compartments that together regulate various sorting and signalling events. Although it is clear that defects in endocytic function underlie a variety of human diseases, our understanding of the molecular entities that regulate these sorting and signalling events remains limited. Here we discuss the sorting nexins family of proteins and propose that they have a fundamental role in orchestrating the formation of protein complexes that are involved in endosomal sorting and signalling.

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  1. Teasdale, R. D., Loci, D., Houghton, F., Karlsson, L. & Gleeson, P. A. A large family of endosome-localized proteins related to sorting nexin 1. Biochem. J. 358, 7–16 (2001). · DOI
  2. Carlton, J. G., Bujny, M. V., Rutherford, A. & Cullen, P. J. Sorting nexins – unifying trends and new perspectives. Traffic 6, 75–82 (2005). · DOI
  3. Seet, L. F. & Hong, W. The Phox (PX) domain proteins and membrane traffic. Biochim. Biophys. Acta 1761, 878–896 (2006). · DOI
  4. Rogaeva, E. et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nature Genet. 39, 168–177 (2007). · DOI · Paper page
  5. Alto, N. M. et al. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J. Cell Biol. 178, 1265–1278 (2007). · DOI
  6. Bonifacino, J. S. & Rojas, R. Retrograde transport from endosomes to the trans-Golgi network. Nature Rev. Mol. Cell Biol. 7, 568–579 (2006). · DOI
  7. Soldati, T. & Schliwa, M. Powering membrane traffic in endocytosis and recycling. Nature Rev. Mol. Cell Biol. 7, 897–908 (2006). · DOI
  8. Carlton, J. G. et al. Sorting nexin-1 mediates tubular endosome-to-TGN transport through co-incidence sensing of high curvature membranes and 3-phosphoinositides. Curr. Biol. 14, 1791–1800 (2004). · DOI · Paper page
  9. McMahon, H. T & Gallop, J. L. Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 438, 590–596 (2005). · DOI
  10. Carlton, J. G. & Cullen, P. J. Co-incidence detection in phosphoinositide signalling. Trends Cell Biol. 15, 540–547 (2005). · DOI
  11. Yarar, D., Waterman-Storer, C. M. & Schmid, S. L. SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev. Cell 13, 43–56 (2007). · DOI
  12. Traer, C. J. et al. Sorting nexin-4 co-ordinates endosomal sorting of transferrin receptor with dynein-mediated transport into the endocytic recycling compartment. Nature Cell Biol. 9, 1370–1380 (2007). · DOI · Paper page
  13. Yarar, D., Surka, M. C., Leonard, M. C. & Schmid, S. L. SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains. Traffic 9, 133–146 (2008). · DOI
  14. Shimada, A. et al. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell 129, 761–772 (2007). · DOI
  15. Frost, A. et al. Structural basis of membrane invagination by F-BAR domains. Cell 132, 807–817 (2008). · DOI
  16. Pylypenko, O., Lundmark, R., Rasmuson, E., Carlsson, S. R. & Rak, A. The PX-BAR membrane-remodeling unit of sorting nexin 9. EMBO J. 26, 4788–4800 (2007). · DOI
  17. Mari, M. et al. Sortilin and mannose 6-phosphate receptors define an exit from early endosomal vacuoles for SNX1-dependent recycling to the TGN. Traffic 9, 380–393 (2008). · DOI
  18. Seaman, M. N. Recycle your receptors with retromer. Trends Cell Biol. 15, 68–75 (2005). · DOI · Paper page
  19. Bonifacino, J. S. & Hurley, J. H. Retromer. Curr. Opin. Cell Biol. 9 May 2008 (doi: 10.1016/j.ceb.2008.03.009). · DOI · Paper page
  20. Hierro, A. et al. Functional architecture of the retromer cargo-recognition complex. Nature 449, 1063–1067 (2007). · DOI · Paper page
  21. Vergés, M. et al. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biol. 6, 763–769 (2004). · DOI
  22. Coudreuse, D. Y., Roel, G., Betist, M. C., Destree, O. & Korswagen, H. C. Wnt gradient formation requires retromer function in Wnt-producing cells. Science 312, 921–924 (2006). · DOI
  23. Prasad, B. C. & Clark, S. G. Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans. Development 133, 1757–1766 (2006). · DOI
  24. Belenkaya, T. Y. et al. The retromer complex influences Wnt secretion by recycling Wntless from endosomes to the trans-Golgi network. Dev. Cell 14, 120–131 (2008). · DOI
  25. Pan, C.-L. et al. C. elegans AP-2 and retromer control Wnt signaling by regulating MIG-14/Wntless. Dev. Cell 14, 132–139 (2008). · DOI
  26. Yang, P.-T. et al. Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells. Dev. Cell 14, 140–147 (2008). · DOI
  27. Franch-Marro, X. et al. Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nature Cell Biol. 10, 170–177 (2008). · DOI
  28. Port, F. et al. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nature Cell Biol. 10, 178–185 (2008). · DOI
  29. Jaillais, Y. Fobis-Loisy, I., Miège, C., Rollin, C. & Gaude, T. AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis. Nature 443, 106–109 (2006). · DOI
  30. Jaillais, Y. The retromer protein VPS29 links cell polarity and organ initiation in plants. Cell 130, 1057–1070 (2007). · DOI
  31. Korolchuk, V. I. et al. Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation. J. Cell Sci. 120, 4367–4376 (2007). · DOI · Paper page
  32. Bujny, M. V., Poppoff, V., Johannes, L. & Cullen, P. J. The retromer component, sorting nexin-1, is required for efficient retrograde transport of Shiga toxin from early endosome to the trans-Golgi network. J. Cell Sci. 120, 2010–2021 (2007). · DOI
  33. Popoff, V. et al. The retromer complex and clathrin define an early endosomal retrograde exit site. J. Cell Sci. 120, 2022–2031 (2007). · DOI
  34. Utskarpen, A., Slagsvold, H. H., Dyve, A. B., Skånland, S. S. & Sandvig, K. SNX1 and SNX2 mediate retrograde transport of Shiga toxin. Biochem. Biophys. Res. Commun. 358, 566–570 (2007). · DOI
  35. Skånland, S. S., Wälchli, S., Utskarpen, A., Wandinger-Ness, A. & Sandvig, K. Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Traffic 8, 297–309 (2007). · DOI
  36. Nielsen, M. S. et al. Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol. Cell. Biol. 27, 6842–6851 (2007). · DOI · Paper page
  37. Small, S. A. et al. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann. Neurol. 58, 909–919 (2005). · DOI · Paper page
  38. He, X., Li, F., Chang, W. P. & Tang, J. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J. Biol. Chem. 280, 11696–11703 (2005). · DOI
  39. Griffin, C. T., Trejo, J. & Magnuson, T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc. Natl Acad. Sci. USA 102, 15173–15177 (2005). · DOI
  40. Carlton, J. G. et al. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J. Cell Sci. 118, 4527–4539 (2005). · DOI
  41. Rojas, R., Kametaka, S., Haft, C. R. & Bonifacino, J. S. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol. Cell. Biol. 27, 1112–1124 (2007). · DOI
  42. Wassmer, T. et al. A loss-of-function screen reveals sorting nexin-5 and sorting nexin-6 as potential components of the mammalian retromer. J. Cell Sci. 120, 45–54 (2007). · DOI
  43. Liu, H. et al. Inhibitory regulation of EGF receptor degradation by sorting nexin 5. Biochem. Biophys. Res. Commun. 342, 537–546 (2006). · DOI
  44. Seaman, M. N. Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval. J. Cell Sci. 120, 2378–2389 (2007). · DOI
  45. Gokool, S., Tattersall, D. & Seaman, M. N. EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval. Traffic 8, 1873–1886 (2007). · DOI
  46. Ganley, I. G., Espinosa, E. & Pfeffer, S. R. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. J. Cell Biol. 283, 159–172 (2008). · DOI
  47. Strochlic, T. I., Setty, T. G., Sitaram, A. & Burd, C. G. Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J. Cell Biol. 177, 115–125 (2007). · DOI · Paper page
  48. Pelham, H. R. Insights from yeast endosomes. Curr. Opin. Cell Biol. 14, 454–462 (2002). · DOI
  49. Lundmark, R. & Carlsson, S. R. Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. J. Biol. Chem. 279, 42694–42702 (2004). · DOI
  50. Soulet, F., Yarar, D., Leonard, M. & Schmid, S. L. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol. Biol. Cell 16, 2058–2067 (2005). · DOI
  51. Badour, K. et al. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc. Natl Acad. Sci. USA 104, 1593–1598 (2007). · DOI
  52. Håberg, K., Lundmark, R. & Carlsson, S. R. SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking. J. Cell Sci. 121, 1495–1505 (2008). · DOI
  53. Hettema, E. H., Lewis, M. J., Black, M. W. & Pelham, H. R. Retromer and the sorting nexins Snx4/41/42 mediate distinct retrieval pathways from yeast endosomes. EMBO J. 22, 548–557 (2003). · DOI
  54. Maxfield, F. R. & McGraw, T. E. Endocytic recycling. Nature Rev. Mol. Cell Biol. 5, 121–132 (2004). · DOI · Paper page
  55. Hoepfner, S. et al. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell 121, 437–450 (2005). · DOI
  56. Zheng, B. et al. Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc. Natl Acad. Sci. USA 103, 16776–16781 (2006). · DOI
  57. Zheng, B. et al. RGS-PX1, a GAP for Gαs and sorting nexin in vesicular trafficking. Science 294, 1939–1942 (2001). · DOI
  58. Zheng, B. et al. Regulation of epidermal growth factor receptor degradation by heterotrimeric Gαs protein. Mol. Biol. Cell 15, 5538–5550 (2004). · DOI
  59. Lunn, M. L. et al. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nature Neurosci. 10, 1249–1259 (2007). · DOI · Paper page
  60. Rincón, E. et al. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase ζ-associated protein: new diacylglycerol kinase roles in endocytic recycling. Mol. Cell. Proteomics 6, 1073–1087 (2007). · DOI
  61. MacNeil, A. J., Mansour, M. & Pohajdak, B. Sorting nexin 27 interacts with the cytohesin associated scaffolding protein (CASP) in lymphocytes. Biochem. Biophys. Res. Commun. 359, 848–853 (2007). · DOI
  62. Williams, R. L. & Urbé, S. The emerging shape of the ESCRT machinery. Nature Rev. Mol. Cell Biol. 8, 355–368 (2007). · DOI
  63. Kärkkäinen, S. et al. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. EMBO Rep. 7, 186–191 (2006). · DOI
  64. Qin, B., He, M., Chen, X. & Pei, D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J. Biol. Chem. 281, 36891–26896 (2006). · DOI
  65. Schaff, U. Y. et al. SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1. Eur. J. Immunol. 38, 550–564 (2008). · DOI
  66. Shin, N. et al. SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell Sci. 121, 1252–1263 (2008). · DOI
  67. Rutherford, A. C. et al. The mammalian phosphatidylinositol 3 monophosphate 5-kinase PIKfyve regulates endosome-to-TGN retrograde transport. J. Cell Sci. 119, 3944–3957 (2006). · DOI
  68. Zhang, Y. et al. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3, 5-bisphosphate, results in neurodegeneration in mice. Proc. Natl Acad. Sci. USA 104, 17518–17523 (2007). · DOI
  69. Dove, S. K. et al. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 23, 1922–1933 (2004). · DOI
  70. Jeffries, T. R., Dove, S. K., Michell, R. H. & Parker, P. J. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol. Biol. Cell 15, 2652–2663 (2004). · DOI
  71. Kerr, M. C. et al. A novel mammalian retromer component, Vps26B. Traffic 6, 991–1001 (2005). · DOI · Paper page
  72. Shi, H., Rojas, R., Bonifacino, J. S. & Hurley, J. H. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nature Struct. Mol. Biol. 13, 540–548 (2006). · DOI
  73. Collins, B. M. et al. Structure of Vps26B and mapping of its interaction with the retromer protein complex. Traffic 9, 366–379 (2008). · DOI
  74. Wang, D. et al. Crystal structure of human Vps29 reveals a phosphodiesterase/nuclease-like fold and two protein–protein interaction sites. J. Biol. Chem. 280, 22962–22967 (2005). · DOI
  75. Collins, B. M., Skinner, C. F., Watson, P. J., Seaman, M. N. & Owen, D. J. Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Nature Struct. Mol. Biol. 12, 594–602 (2005). · DOI
  76. Gokool, S., Tattersall, D., Reddy, J. V. & Seaman, M. N. Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem. J. 408, 287–295 (2007). · DOI
  77. Restrepo, R. et al. Structural features of vps35p involved in interaction with other subunits of the retromer complex. Traffic 8, 1841–1853 (2007). · DOI
  78. Zhao, X. et al. Dominant-negative behaviour of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic 8, 1829–1840 (2007). · DOI
  79. Haft, C. R. et al. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol. Biol. Cell 11, 4105–4116 (2000). · DOI · Paper page
  80. Mayor, S. & Pagano, R. E. Pathways of clathrin-independent endocytosis. Nature Rev. Mol. Cell Biol. 8, 603–612 (2007). · DOI · Paper page

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Metadata

Authors
Cullen, P. J.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2008-06-04
Volume
9
Issue
7
Pages
574-582
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm2427
Cited by
404
References
3
Language
en
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