The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
Abstract
Dendritic cell specific intracellular adhesion molecule–3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.
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Cited by
C-type lectin receptors on dendritic cells and langerhans cells
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The repertoire of glycan determinants in the human glycome
Cummings, R. D. (2009) · Molecular BioSystems · doi:10.1039/b907931a · Cited by 487
Metadata
- Authors
- Feinberg, H., Mitchell, D. A., Drickamer, K., & Weis, W. I.
- Venue
- Science
- Published
- 2001-12-07
- Volume
- 294
- Issue
- 5549
- Pages
- 2163-2166
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012657759
- Cited by
- 676
- References
- 18
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
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