C-type lectin receptors on dendritic cells and langerhans cells

Figdor, Carl G.; van Kooyk, Yvette; Adema, Gosse J.

doi:10.1038/nri723

Cited by 842Immunotherapy and Immune ResponsesImmune Response and InflammationHistiocytic Disorders and Treatments

C-type lectin receptors on dendritic cells and langerhans cells

Figdor, Carl G., van Kooyk, Yvette, Adema, Gosse J.·2002·Nature Reviews Immunology

DOI 10.1038/nri723

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Abstract

Dendritic cells and Langerhans cells are specialized for the recognition of pathogens and have a pivotal role in the control of immunity. As guardians of the immune system, they are present in essentially every organ and tissue, where they operate at the interface of innate and acquired immunity. Recently, several C-type lectin and lectin-like receptors have been characterized that are expressed abundantly on the surface of these professional antigen-presenting cells. It is now becoming clear that lectin receptors not only serve as antigen receptors but also regulate the migration of dendritic cells and their interaction with lymphocytes.

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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
Sallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501 · see citing works
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
Geijtenbeek, T. B. H., Kwon, D. S., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Middel, J., Cornelissen, I. L. M. H. A., Nottet, H. S. L. M., KewalRamani, V. N., Littman, D. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80694-7 · Cited by 2,447 · see citing works
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Geijtenbeek, T. B. H., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Adema, G. J., van Kooyk, Y., & Figdor, C. G. (2000) · Cell · doi:10.1016/s0092-8674(00)80693-5 · Cited by 1,701 · see citing works
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Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579 · see citing works
BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood
Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D., & Schmitz, J. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.11.6037 · Cited by 1,433 · see citing works
Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site
Ren, R., Mayer, B. J., Cicchetti, P., & Baltimore, D. (1993) · Science · doi:10.1126/science.8438166 · Cited by 1,191 · see citing works
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., Lustig, D. S., & Cohn, Z. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.6.1431 · Cited by 1,052 · see citing works
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
Jiang, W., Swiggard, W. J., Heufler, C., Peng, M., Mirza, A., Steinman, R. M., & Nussenzweig, M. C. (1995) · Nature · doi:10.1038/375151a0 · Cited by 966 · see citing works
Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, Is an Endocytic Receptor that Induces the Formation of Birbeck Granules
Valladeau‐Guilemond, J., Ravel, O., Dezutter‐Dambuyant, C., Moore, K. W., Kleijmeer, M. J., Liu, Y., Duvert-Frances, V., Vincent, C., Schmitt, D., Davoust, J. M., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80160-0 · Cited by 961 · see citing works
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., & Cohn, Z. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.2.380 · Cited by 817 · see citing works
BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction
Dzionek, A., Sohma, Y., Nagafune, J., Cella, M., Colonna, M., Facchetti, F., Günther, G., Johnston, I., Lanzavecchia, A., Nagasaka, T., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.12.1823 · Cited by 765 · see citing works
The Toll receptor family and microbial recognition.
Medzhitov, R., & Janeway, C. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01845-x · Cited by 739 · see citing works
Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
Feinberg, H., Mitchell, D. A., Drickamer, K., & Weis, W. I. (2001) · Science · doi:10.1126/science.1066371 · Cited by 678 · see citing works
The mannose receptor is a pattern recognition receptor involved in host defense
Stahl, P. D., & Ezekowitz, R. A. B. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80031-9 · Cited by 639 · see citing works
The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells
Engering, A. J., Geijtenbeek, T. B. H., van Vliet, S. J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J. A. M., Figdor, C. G., Piguet, V., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.5.2118 · Cited by 630 · see citing works
Self-citation
Local control of the immune response in the liver
Knolle, P. A., & Gerken, G. (2000) · Immunological Reviews · doi:10.1034/j.1600-0528.2002.017408.x · Cited by 610 · see citing works
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
Stahl, P. D., Schlesinger, P. H., Sigardson, E., Rodman, J. S., & Lee, Y. C. (1980) · Cell · doi:10.1016/0092-8674(80)90402-x · Cited by 569 · see citing works
The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments
Mahnke, K., Guo, M., Lee, S., Sepulveda, H., Swain, S. L., Nussenzweig, M. C., & Steinman, R. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.673 · Cited by 544 · see citing works
A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR
Mitchell, D. A., Fadden, A. J., & Drickamer, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104565200 · Cited by 502 · see citing works
DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking
Geijtenbeek, T. B. H., Krooshoop, D. J. E. B., Bleijs, D. A., van Vliet, S. J., van Duijnhoven, G. C. F., Grabovsky, V., Alon, R., Figdor, C. G., & van Kooyk, Y. (2000) · Nature Immunology · doi:10.1038/79815 · Cited by 498 · see citing works
Self-citation
Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning
Ariizumi, K., Shen, G.-L., Shikano, S., Xu, S., Ritter, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R., & Takashima, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909512199 · Cited by 468 · see citing works
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.
de Fougerolles, A. R., & Springer, T. A. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.185 · Cited by 432 · see citing works
Molecular Bases for the Recognition of Tyrosine-based Sorting Signals
Bonifacino, J. S., & Dell’Angelica, E. C. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.923 · Cited by 421 · see citing works
The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells
Engering, A. J., Cella, M., Fluitsma, D. M., Brockhaus, M., Hoefsmit, E. C. M., Lanzavecchia, A., & Pieters, J. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270941 · Cited by 400 · see citing works
A Novel Lysosome-Associated Membrane Glycoprotein, DC-LAMP, Induced upon DC Maturation, Is Transiently Expressed in MHC Class II Compartment
de Saint-Vis, B., Vincent, J., Vandenabeele, S., Vanbervliet, B., Pin, J., Aït‐Yahia, S., Patel, S., Mattéi, M., Banchereau, J., Zurawski, S., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80615-9 · Cited by 399 · see citing works
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients
Soumelis, V., Scott, I., Gheyas, F., Bouhour, D., Cozon, G. J. N., Cotte, L., Huang, L., Levy, J. A., & Liu, Y. (2001) · Blood · doi:10.1182/blood.v98.4.906 · Cited by 397 · see citing works
Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.
Curtis, B. M., Scharnowske, S., & Watson, A. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8356 · Cited by 385 · see citing works
Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains.
Taylor, M. E., Conary, J. T., Lennartz, M. R., Stahl, P. D., & Drickamer, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38325-5 · Cited by 371 · see citing works
A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
Bashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B. G., Martin, M. P., Wu, L. J., Martin, T. D., Viebig, N. K., Knolle, P. A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.671 · Cited by 358 · see citing works
DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
Pöhlmann, S., Soilleux, E. J., Baribaud, F., Leslie, G. J., Morris, L. S., Trowsdale, J., Lee, B., Coleman, N., & Doms, R. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051631398 · Cited by 324 · see citing works
APCs Express DCIR, a Novel C-Type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif
Bates, E. E. M., Fournier, N., Garcia, E., Valladeau‐Guilemond, J., Durand, I., Pin, J., Zurawski, S., Patel, S., Abrams, J. S., Lebecque, S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1973 · Cited by 269 · see citing works
Cutting Edge: DC-SIGN; a Related Gene, DC-SIGNR; and CD23 Form a Cluster on 19p13
Soilleux, E. J., Barten, R., & Trowsdale, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.2937 · Cited by 262 · see citing works
Isolation and Characterization of a Mannan-Binding Protein from Human Serum1
Kawasaki, N., Kawasaki, T., & Yamashina, I. (1983) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a134437 · Cited by 235 · see citing works
A Novel Phosphotyrosine Motif with a Critical Amino Acid at Position −2 for the SH2 Domain-mediated Activation of the Tyrosine Phosphatase SHP-1*
Burshtyn, D., Yang, W.-T., Yi, T., & Long, E. O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13066 · Cited by 219 · see citing works
The Cysteine-Rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates a and B and Sulfated Oligosaccharides of Blood Group Lewisa and Lewisx Types in Addition to the Sulfated N-Glycans of Lutropin
Leteux, C., Chai, W., Loveless, R. W., Yuen, C., Uhlin‐Hansen, L., Combarnous, Y., Janković, M., Maric, S. C., Misulovin, Z., Nussenzweig, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1117 · Cited by 168 · see citing works
Cloning of a Second Dendritic Cell-associated C-type Lectin (Dectin-2) and Its Alternatively Spliced Isoforms
Ariizumi, K., Shen, G.-L., Shikano, S., Ritter, R., Zukas, P. K., Edelbaum, D., Morita, A., & Takashima, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11957 · Cited by 164 · see citing works
Carbohydrate-mediated recognition systems in innate immunity
Feizi, T. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917310.x · Cited by 161 · see citing works
Expression of multilectin receptors and comparative FITC–dextran uptake by human dendritic cells
Kato, M., Neil, T. K., Fearnley, D. B., McLellan, A. D., Vučković, S., & Hart, D. N. J. (2000) · International Immunology · doi:10.1093/intimm/12.11.1511 · Cited by 160 · see citing works
C-Type lectin-like domains in Caenorhabditis elegans: predictions from the complete genome sequence
Drickamer, K., & Dodd, R. B. (1999) · Glycobiology · doi:10.1093/glycob/9.12.1357 · Cited by 136 · see citing works
Divergent functions of lectin‐like receptors on NK cells
Ryan, J. C., & Seaman, W. E. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00941.x · Cited by 133 · see citing works
The role of dendritic cells in the innate immune system
Clark, G. J., Angel, N. Z., Kato, M., López, J. A., MacDonald, K. P. A., Vučković, S., & Hart, D. N. J. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00302-6 · Cited by 122 · see citing works
Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis
Valladeau‐Guilemond, J., Duvert-Frances, V., Pin, J., Kleijmeer, M. J., Aït‐Yahia, S., Ravel, O., Vincent, C., Vega, F., Helms, A., Gorman, D., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5767 · Cited by 116 · see citing works
C-Type Lectins and Sialyl Lewis X Oligosaccharides
Fukuda, M., Hiraoka, N., & Yeh, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.467 · Cited by 115 · see citing works
Extensive Repertoire of Membrane-bound and Soluble Dendritic Cell-specific ICAM-3-grabbing Nonintegrin 1 (DC-SIGN1) and DC-SIGN2 Isoforms
Mummidi, S., Catano, G., Lam, L., Hoefle, A., Telles, V., Begum, K., Jiménez, F., Ahuja, S. S., & Ahuja, S. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009807200 · Cited by 104 · see citing works
Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1
Yokota, K., Takashima, A., Bergstresser, P. R., & Ariizumi, K. (2001) · Gene · doi:10.1016/s0378-1119(01)00528-5 · Cited by 103 · see citing works
Secretion of TNF-α by alveolar macrophages in response to Candida albicans mannan
Garner, R. E., Rubanowice, K., Sawyer, R. T., & Hudson, J. A. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.2.161 · Cited by 102 · see citing works
cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells
Kato, M., Neil, T. K., Clark, G. J., et al. (1998) · Immunogenetics · doi:10.1007/s002510050381 · Cited by 70 · see citing works
Human dendritic cells shed a functional, soluble form of the mannose receptor
Jordens, R., Thompson, A., Amons, R., et al. (1999) · International Immunology · doi:10.1093/intimm/11.11.1775 · Cited by 62 · see citing works
Dermal Microvascular Endothelial Cells Express the 180-kDa Macrophage Mannose Receptor In Situ and In Vitro
Gröger, M., Holnthoner, W., Maurer, D., Lechleitner, S., Wolff, K. S., Mayr, B., Lubitz, W., & Petzelbauer, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5428 · Cited by 61 · see citing works
Structure of the gene coding for the human early lymphocyte activation antigen CD69: A C‐type lectin receptor evolutionarily related with the gene families of natural killer cell‐specific receptors
Santis, A. G., López‐Cabrera, M., Hamann, J., et al. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240735 · Cited by 60 · see citing works
New structural insights into lectin-type proteins of the immune system
Kogelberg, H., & Feizi, T. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00259-1 · Cited by 56 · see citing works
CD69, An Early Activation Antigen on Lymphocytes, Is Constitutively Expressed by Human Epidermal Langerhans Cells
Bieber, T., Rieger, A., Stingl, G., et al. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12499948 · Cited by 43 · see citing works
The interaction of a lung surfactant protein (SP-A) with macrophages is mannose dependent.
Wintergerst, E. S., Manz-Keinke, H., Plattner, H., et al. (1989) · PubMed · Cited by 41 · see citing works
Cloning and Characterization of a Novel ITIM Containing Lectin-like Immunoreceptor LLIR and Its Two Transmembrane Region Deletion Variants
Huang, X., Yuan, Z., Chen, G., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4322 · Cited by 36 · see citing works
Differentially induced expression of C-type lectins in activated lymphocytes
Eichler, W., Ruschpler, P., Wobus, M., et al. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1107 · Cited by 24 · see citing works
The ins and outs of getting in: structures and signals that enhance BCR or Fc receptor-mediated antigen presentation
Shen, L., Lang, M. L., & Wade, W. F. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)00255-1 · Cited by 12 · see citing works
Post-transcriptional regulation of E2A proteins via lipopolysaccharide and CD40 signaling
Meyer, K. B., & Mufti, D. A. H. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200002)30:2 · Cited by 8 · see citing works
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Innate Immune Recognition of the Pathogenic Fungus by Toll-Like Receptors
Jing, Z., He, X., & HuaiJie, J. (2012) · Zhongguo shengwu gongcheng zazhi

Authors: Figdor, C. G., van Kooyk, Y., & Adema, G. J.
Affiliations: Radboud University Nijmegen (NL)
Corresponding author: Figdor, Carl G.
ORCID: Figdor, Carl G.
Adema, Gosse J.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2002-02-01
Volume: 2
Issue: 2
Pages: 77-84
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri723
OpenAlex: W2087166273
Cited by: 842
References: 59
Citations by year: 2026: 7 · 2025: 12 · 2024: 16 · 2023: 24 · 2022: 24 · 2021: 28 · 2020: 24 · 2019: 20 · 2018: 26 · 2017: 35 · 2016: 26 · 2015: 29 · 2014: 51 · 2013: 25 · 2012: 52
FWCI: 3.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Physiology › Histiocytic Disorders and Treatments
Keywords: C-type lectin receptors, dendritic cells, Langerhans cells, antigen presentation, innate immunity, dendritic cell migration, pathogen recognition, lectin-like receptors
MeSH terms: Animals, Cell Communication, Cell Movement, Dendritic Cells, Endothelium, Vascular, Humans, Langerhans Cells, Lectins, Lectins, C-Type

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C-type lectin receptors on dendritic cells and langerhans cells

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