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Array-Based Electrical Detection of DNA with Nanoparticle Probes
Abstract
A DNA array detection method is reported in which the binding of oligonucleotides functionalized with gold nanoparticles leads to conductivity changes associated with target-probe binding events. The binding events localize gold nanoparticles in an electrode gap; silver deposition facilitated by these nanoparticles bridges the gap and leads to readily measurable conductivity changes. An unusual salt concentration–dependent hybridization behavior associated with these nanoparticle probes was exploited to achieve selectivity without a thermal-stringency wash. Using this method, we have detected target DNA at concentrations as low as 500 femtomolar with a point mutation selectivity factor of ∼ 100,000:1.
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Cited by
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Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Self-citationGhosh, S. K., & Pal, T. (2007) · Chemical Reviews · doi:10.1021/cr0680282 · Cited by 2,782
Electrochemical Biosensors - Sensor Principles and Architectures
Grieshaber, D., MacKenzie, R., Vörös, J., & Reimhult, E. (2008) · Sensors · doi:10.3390/s80314000 · Cited by 2,329
Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
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Liz-Marzán, L. M. (2006) · Langmuir · doi:10.1021/la0513353 · Cited by 1,645
Metadata
- Authors
- Park, S.-J., Taton, T. A., & Mirkin, C. A.
- Venue
- Science
- Published
- 2002-02-22
- Volume
- 295
- Issue
- 5559
- Pages
- 1503-1506
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2153321597
- Cited by
- 1,515
- References
- 0
- FWCI
- 31.43
- Type
- journal article
- Language
- en
- Open access
- closed
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