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Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Abstract
Single-cell mouse embryos were infected in vitro with recombinant lentiviral vectors to generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter . Eighty percent of founder mice carried at least one copy of the transgene, and 90% of these expressed GFP at high levels. Progeny inherited the transgene(s) and displayed green fluorescence. Mice generated using lentiviral vectors with muscle-specific and T lymphocyte–specific promoters expressed high levels of GFP only in the appropriate cell types. We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce other transgenic animal species.
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In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903
Development of a self-inactivating lentivirus vector
Miyoshi, H., Blömer, U., Takahashi, M., Gage, F. H., & Verma, I. M. (1998) · Journal of Virology · doi:10.1128/jvi.72.10.8150-8157.1998 · Cited by 1,196
Research works printed but not linked: 21
- 10.1126/science.3287623 · DOI · Paper page
- 10.1073/pnas.73.4.1260 · DOI · Paper page
- 10.1038/298623a0 · DOI
- Schmidt E. V., Christoph G., Zeller R., Leder P., Mol. Cell. Biol. 10, 4406 (1990).
- 10.1016/0378-1119(91)90434-D · DOI
- 10.1002/aja.1002000403 · DOI
- 10.1093/nar/24.9.1787 · DOI
- 10.1128/JVI.73.4.2886-2892.1999 · DOI · Paper page
- 10.1016/S0092-8674(00)80828-4 · DOI · Paper page
- B. Hogan R. Beddington F. Costantini E. Lacy Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 1994).
- Supplementary material is available at Science Online at www.sciencemag.org/cgi/content/full/1067081/DC1.
- 10.1101/gad.7.7a.1277 · DOI · Paper page
- 10.1016/S0960-9822(98)70156-3 · DOI · Paper page
- 10.1007/BF01972876 · DOI
- 10.1073/pnas.77.12.7380 · DOI · Paper page
- 10.1093/ps/76.8.1084 · DOI
- J. Coffin S. Hughes H. Varmus Retroviruses (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 1997).
- 10.1016/S0168-9525(97)01181-5 · DOI · Paper page
- 10.1016/S0091-679X(08)60600-7 · DOI
- 10.1093/oxfordjournals.humrep.a137633 · DOI
- 10.1128/jvi.70.8.5701-5705.1996 · DOI · Paper page
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Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
Shekhar, K., Lapan, S. W., Whitney, I. E., Tran, N. M., Macosko, E. Z., Kowalczyk, M., Adiconis, X., Levin, J. Z., Nemesh, J., Goldman, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.054 · Cited by 1,176
Metadata
- Authors
- Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D.
- Venue
- Science
- Published
- 2002-02
- Volume
- 295
- Issue
- 5556
- Pages
- 868-872
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037174767
- Cited by
- 1,999
- References
- 2
- FWCI
- 37.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002). Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors. Science. https://doi.org/10.1126/science.1067081
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