The DOI matches its Crossref record.
Large-Scale Transcriptional Activity in Chromosomes 21 and 22
Abstract
The sequences of the human chromosomes 21 and 22 indicate that there are approximately 770 well-characterized and predicted genes. In this study, empirically derived maps identifying active areas of RNA transcription on these chromosomes have been constructed with the use of cytosolic polyadenylated RNA obtained from 11 human cell lines. Oligonucleotide arrays containing probes spaced on average every 35 base pairs along these chromosomes were used. When compared with the sequence annotations available for these chromosomes, it is noted that as much as an order of magnitude more of the genomic sequence is transcribed than accounted for by the predicted and characterized exons.
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Citations
Cited by
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223
Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
“Having identified K4–K36 loci with no previous annotation, we addressed: (1) whether these gene loci produce large multi-exonic RNA molecules; (2) whether the RNA molecules encode proteins or are non-coding transcripts; and (3) whether the RNA molecules, their promoters and their chromatin structure show conservation…”
Background
Metadata
- Authors
- Kapranov, P., Cawley, S. E., Drenkow, J., Bekiranov, S., Strausberg, R. L., Fodor, S. P. A., & Gingeras, T. R.
- Venue
- Science
- Published
- 2002-05-03
- Volume
- 296
- Issue
- 5569
- Pages
- 916-919
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016927884
- Cited by
- 869
- References
- 0
- FWCI
- 26.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kapranov, P., Cawley, S. E., Drenkow, J., Bekiranov, S., Strausberg, R. L., Fodor, S. P. A., & Gingeras, T. R. (2002). Large-Scale Transcriptional Activity in Chromosomes 21 and 22. Science. https://doi.org/10.1126/science.1068597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
