Evolutionary Rate in the Protein Interaction Network
Abstract
High-throughput screens have begun to reveal the protein interaction network that underpins most cellular functions in the yeast Saccharomyces cerevisiae . How the organization of this network affects the evolution of the proteins that compose it is a fundamental question in molecular evolution. We show that the connectivity of well-conserved proteins in the network is negatively correlated with their rate of evolution. Proteins with more interactors evolve more slowly not because they are more important to the organism, but because a greater proportion of the protein is directly involved in its function. At sites important for interaction between proteins, evolutionary changes may occur largely by coevolution, in which substitutions in one protein result in selection pressure for reciprocal changes in interacting partners. We confirm one predicted outcome of this process—namely, that interacting proteins evolve at similar rates.
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A genome duplication event would, at least initially, increase the number of interactors for each protein, potentially slowing the rate of molecular evolution across the entire genome.
“Despite the fact that gene duplication events are thought to increase rather than decrease the rate of molecular evolution (33), a genome duplication event would (at least initially) increase the number of interactors for each protein, potentially slowing the rate of molecular evolution across the entire genome (34).”
From Estimating metazoan divergence times with a molecular clock (2004) · cites this paper as [34]
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- Authors
- Fraser, H. B., Hirsh, A. E., Steinmetz, L. M., Scharfe, C., & Feldman, M. W.
- Affiliations
- University of California, Berkeley (US)
- Stanford University (US)
- Corresponding author
- Fraser, Hunter B.
- Hirsh, Aaron E.
- Venue
- Science
- Published
- 2002-04-26
- Volume
- 296
- Issue
- 5568
- Pages
- 750-752
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029158589
- Cited by
- 869
- References
- 0
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 16 · 2022: 15 · 2021: 17 · 2020: 38 · 2019: 25 · 2018: 21 · 2017: 24 · 2016: 34 · 2015: 24 · 2014: 36 · 2013: 46 · 2012: 55
- FWCI
- 25.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- protein-protein interaction network, evolutionary rates, network connectivity, coevolution, protein conservation, Saccharomyces cerevisiae, molecular evolution, protein function, selection pressure
- MeSH terms
- Genes, Fungal, Protein Conformation, Saccharomyces cerevisiae, Sequence Alignment, Conserved Sequence, Sequence Homology, Amino Acid, Evolution, Molecular, Computational Biology, Amino Acid Substitution, Protein Footprinting, Saccharomyces cerevisiae Proteins, Caenorhabditis elegans Proteins
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