The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2
Abstract
Thromboxane (Tx) A 2 is a vasoconstrictor and platelet agonist. Aspirin affords cardioprotection through inhibition of TxA 2 formation by platelet cyclooxygenase (COX-1). Prostacyclin (PGI 2 ) is a vasodilator that inhibits platelet function. Here we show that injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI 2 receptor (IP) but are depressed in mice genetically deficient in the TxA 2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors. Thus, PGI 2 modulates platelet-vascular interactions in vivo and specifically limits the response to TxA 2 . This interplay may help explain the adverse cardiovascular effects associated with selective COX-2 inhibitors, which, unlike aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), inhibit PGI 2 but not TxA 2 .
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Cites
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., et al. (1997) · Nature · doi:10.1038/41780 · Cited by 773
Cited by
Platelet Activation and Atherothrombosis
Davì, G., & Patrono, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071014 · Cited by 2,135
Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases
Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.01.016 · Cited by 793
Activation of Platelet Function Through G Protein–Coupled Receptors
Offermanns, S. (2006) · Circulation Research · doi:10.1161/01.res.0000251742.71301.16 · Cited by 725
Diclofenac: an update on its mechanism of action and safety profile
Gan, T. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.486301 · Cited by 600
Endothelium‐dependent contractions in hypertension
Vanhoutte, P. M., Feletou, M., & Taddei, S. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706042 · Cited by 284
Metadata
- Authors
- Cheng, Y., Austin, S. C., Rocca, B., Koller, B. H., Coffman, T. M., Grosser, T., Lawson, J. A., & FitzGerald, G. A.
- Venue
- Science
- Published
- 2002-04-19
- Volume
- 296
- Issue
- 5567
- Pages
- 539-541
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018716226
- Cited by
- 789
- References
- 1
- FWCI
- 39.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, Y., Austin, S. C., Rocca, B., Koller, B. H., Coffman, T. M., Grosser, T., Lawson, J. A., & FitzGerald, G. A. (2002). Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2. Science. https://doi.org/10.1126/science.1068711
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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