Activation of Platelet Function Through G Protein–Coupled Receptors

Offermanns, Stefan

doi:10.1161/01.res.0000251742.71301.16

Cited by 730Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsReceptor Mechanisms and Signaling

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Activation of Platelet Function Through G Protein–Coupled Receptors

Offermanns, Stefan·2006·Circulation Research

DOI 10.1161/01.res.0000251742.71301.16

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Abstract

Because of their ability to become rapidly activated at places of vascular injury, platelets are important players in primary hemostasis as well as in arterial thrombosis. In addition, they are also involved in chronic pathological processes including the atherosclerotic remodeling of the vascular system. Although primary adhesion of platelets to the vessel wall is largely independent of G protein–mediated signaling, the subsequent recruitment of additional platelets into a growing platelet thrombus requires mediators such as ADP, thromboxane A 2 , or thrombin, which act through G protein–coupled receptors. Platelet activation via G protein–coupled receptors involves 3 major G protein–mediated signaling pathways that are initiated by the activation of the G proteins G q , G 13 , and G i . This review summarizes recent progress in understanding the mechanisms underlying platelet activation and thrombus extension via G protein–mediated signaling pathways.

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10.1161/circ.100.15.1667 · DOI
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10.1182/blood.V96.1.50 · DOI
10.1172/JCI200420267 · DOI

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Authors: Offermanns, S.
Affiliations: Heidelberg University (DE)
Corresponding author: Offermanns, Stefan
ORCID: Offermanns, Stefan
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-12-08
Volume: 99
Issue: 12
Pages: 1293-1304
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000251742.71301.16
OpenAlex: W2161488081
Cited by: 725
References: 168
Citations by year: 2026: 32 · 2025: 33 · 2024: 37 · 2023: 30 · 2022: 52 · 2021: 42 · 2020: 37 · 2019: 38 · 2018: 23 · 2017: 53 · 2016: 34 · 2015: 45 · 2014: 33 · 2013: 46 · 2012: 29
FWCI: 3.23
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Circulation Research
Topics: Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: platelet activation, G protein-coupled receptors, G protein signaling, Gq, G13, Gi, thrombus extension, primary hemostasis, arterial thrombosis, atherosclerosis, thromboxane A2, thrombin, ADP, platelet adhesion
MeSH terms: Animals, Blood Platelets, Humans, Thrombosis, Platelet Activation, Receptors, G-Protein-Coupled

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Activation of Platelet Function Through G Protein–Coupled Receptors

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