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Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae
Abstract
Simian virus 40 (SV40) utilizes endocytosis through caveolae for infectious entry into host cells. We found that after binding to caveolae, virus particles induced transient breakdown of actin stress fibers. Actin was then recruited to virus-loaded caveolae as actin patches that served as sites for actin “tail” formation. Dynamin II was also transiently recruited. These events depended on the presence of cholesterol and on the activation of tyrosine kinases that phosphorylated proteins in caveolae. They were necessary for formation of caveolae-derived endocytic vesicles and for infection of the cell. Thus, caveolar endocytosis is ligand-triggered and involves extensive rearrangement of the actin cytoskeleton.
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Cited by
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
Pathways of clathrin-independent endocytosis
Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556
The multiple faces of caveolae
Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,454
Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057
Self-citationDynamin, a membrane-remodelling GTPase
Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
Metadata
- Authors
- Pelkmans, L., Püntener, D., & Helenius, A.
- Venue
- Science
- Published
- 2002-04-19
- Volume
- 296
- Issue
- 5567
- Pages
- 535-539
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034508297
- Cited by
- 720
- References
- 0
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pelkmans, L., Püntener, D., & Helenius, A. (2002). Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae. Science. https://doi.org/10.1126/science.1069784
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