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Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches
Abstract
How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin–mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/β-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these proteins from GSCs results in stem cell loss. Furthermore, DE-cadherin is required for recruiting GSCs to their niche. Our study demonstrates that anchorage of GSCs in their niche by DE-cadherin–mediated adhesion is important for stem cell maintenance and function.
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Cited by
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Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656
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Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823
Perez-Moreno, M., Jamora, C., & Fuchs, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00108-9 · Cited by 721
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451
A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors
Mandal, L., Martinez-Agosto, J. A., Evans, C. J., Hartenstein, V., & Banerjee, U. (2007) · Nature · doi:10.1038/nature05585 · Cited by 310
Metadata
- Authors
- Song, X., Zhu, C.-H., Doan, C., & Xie, T.
- Venue
- Science
- Published
- 2002-06-07
- Volume
- 296
- Issue
- 5574
- Pages
- 1855-1857
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027384096
- Cited by
- 483
- References
- 0
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, X., Zhu, C.-H., Doan, C., & Xie, T. (2002). Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches. Science. https://doi.org/10.1126/science.1069871
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