The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila
Abstract
Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-κB family transcription factor Relish.
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Cites
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Self-citationRelish, a Central Factor in the Control of Humoral but Not Cellular Immunity in Drosophila
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Self-citationPurification of a Peptidoglycan Recognition Protein from Hemolymph of the Silkworm, Bombyx mori
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Cited by
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors in innate immunity
Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328
The Host Defense of Drosophila melanogaster
Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
Insect hemocytes and their role in immunity
Lavine, M. D., & Strand, M. R. (2002) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(02)00092-9 · Cited by 1,632
Metadata
- Authors
- Choe, K.-M., Werner, T., Stöven, S., Hultmark, D., & Anderson, K. V.
- Venue
- Science
- Published
- 2002-04-12
- Volume
- 296
- Issue
- 5566
- Pages
- 359-362
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994599007
- Cited by
- 607
- References
- 25
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila. https://app.cochat.ai/papers/10.1126/science.1070216
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- Choe, K.-M., Werner, T., Stöven, S., Hultmark, D., & Anderson, K. V. (2002). Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila. Science. https://doi.org/10.1126/science.1070216
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
