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Role of Delayed Nuclear Envelope Breakdown and Mitosis in Wolbachia -Induced Cytoplasmic Incompatibility
Abstract
The bacterium Wolbachia manipulates reproduction in millions of insects worldwide; the most common effect is cytoplasmic incompatibility (CI). We found that CI resulted from delayed nuclear envelope breakdown of the male pronucleus in Nasonia vitripennis . This caused asynchrony between the male and female pronuclei and, ultimately, loss of paternal chromosomes at the first mitosis. When Wolbachia were present in the egg, synchrony was restored, which explains suppression of CI in these crosses. These results suggest that Wolbachia target cell cycle regulatory proteins. A striking consequence of CI is that it alters the normal pattern of reciprocal centrosome inheritance in Nasonia.
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Cited by
Wu, M., Sun, L. V., Vamathevan, J., Riegler, M., Deboy, R., Brownlie, J. C., McGraw, E. A., Martin, W., Esser, C., Ahmadinejad, N., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020069 · Cited by 851
“…of cell-cycle-regulating proteins in D. melanogaster contain ankyrin repeats (Elfring et al. 1997); and (iv) the Wolbachia strain that infects the wasp Nasonia vitripennis induces cytoplasmic incompatibility, likely by interacting with these same cell-cycle proteins (Tram and Sullivan 2002).”
Wolbachia Establishment and Invasion in an Aedes aegypti Laboratory Population
Xi, Z., Khoo, C. C. H., & Dobson, S. L. (2005) · Science · doi:10.1126/science.1117607 · Cited by 554
Bouchon, D., Zimmer, M., & Dittmer, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01472 · Cited by 110
Proteomics of Nasonia vitripennis and the effects of native Wolbachia infection on N. vitripennis
Li, J., Wang, N., Liu, Y., & Qiu, S. (2018) · PeerJ · doi:10.7717/peerj.4905 · Cited by 8
Metadata
- Authors
- Tram, U., & Sullivan, W.
- Venue
- Science
- Published
- 2002-05-10
- Volume
- 296
- Issue
- 5570
- Pages
- 1124-1126
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090362564
- Cited by
- 247
- References
- 0
- FWCI
- 24.84
- Type
- journal article
- Language
- en
- Open access
- closed
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