The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Visualization and Functional Analysis of RNA-Dependent RNA Polymerase Lattices
Abstract
Positive-strand RNA viruses such as poliovirus replicate their genomes on intracellular membranes of their eukaryotic hosts. Electron microscopy has revealed that purified poliovirus RNA-dependent RNA polymerase forms planar and tubular oligomeric arrays. The structural integrity of these arrays correlates with cooperative RNA binding and RNA elongation and is sensitive to mutations that disrupt intermolecular contacts predicted by the polymerase structure. Membranous vesicles isolated from poliovirus-infected cells contain structures consistent with the presence of two-dimensional polymerase arrays on their surfaces during infection. Therefore, host cytoplasmic membranes may function as physical foundations for two-dimensional polymerase arrays, conferring the advantages of surface catalysis to viral RNA replication.
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Cites
Paul, A. V., Mugavero, J., Yin, J., Hobson, S., Schultz, S., van Boom, J. H., & Wimmer, E. (2000) · Virology · doi:10.1006/viro.2000.0354 · Cited by 48
Cited by
Common and unique features of viral RNA-dependent polymerases
te Velthuis, A. J. W. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1695-z · Cited by 275
Alirezaei, M., Flynn, C. T., Wood, M. R., & Whitton, J. L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.014 · Cited by 82
Making of Viral Replication Organelles by Remodeling Interior Membranes
Sasvari, Z., & Nagy, P. D. (2010) · Viruses · doi:10.3390/v2112436 · Cited by 32
(2024) · doi:10.1038/s41467-024-46601-4 · Cited by 14
Metadata
- Authors
- Lyle, J. M., Bullitt, E., Bienz, K., & Kirkegaard, K.
- Venue
- Science
- Published
- 2002-06-21
- Volume
- 296
- Issue
- 5576
- Pages
- 2218-2222
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022618835
- Cited by
- 162
- References
- 1
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
