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Female Germ Cell Aneuploidy and Embryo Death in Mice Lacking the Meiosis-Specific Protein SCP3
Abstract
Aneuploidy (trisomy or monosomy) is the leading genetic cause of pregnancy loss in humans and results from errors in meiotic chromosome segregation. Here, we show that the absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation. The abnormal oocyte karyotype is inherited by embryos, which die in utero at an early stage of development. In addition, embryo death in SCP3 -deficient females increases with advancing maternal age. We found that SCP3 is required for chiasmata formation and for the structural integrity of meiotic chromosomes, suggesting that altered chromosomal structure triggers nondisjunction. SCP3 is thus linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.
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Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805
Cited by
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White, Y. A. R., Woods, D. C., Takai, Y., Ishihara, O., Seki, H., & Tilly, J. L. (2012) · Nature Medicine · doi:10.1038/nm.2669 · Cited by 719
THE GENETICS AND MOLECULAR BIOLOGY OF THE SYNAPTONEMAL COMPLEX
Page, S. L., & Hawley, R. S. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.155141 · Cited by 709
The origin of human aneuploidy: where we have been, where we are going
Hassold, T., Hall, H., & Hunt, P. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm243 · Cited by 649
Production of offspring from a germline stem cell line derived from neonatal ovaries
Zou, K., Yuan, Z., Yang, Z., Luo, H., Sun, K., Zhou, L., Xiang, J., Shi, L., Yu, Q., Zhang, Y., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1869 · Cited by 624
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Matzuk, M. M., & Lamb, D. J. (2002) · Nature Cell Biology · doi:10.1038/ncb-nm-fertilitys41 · Cited by 579
Metadata
- Authors
- Yuan, L., Liu, J.-G., Hoja, M.-R., Wilbertz, J., Nordqvist, K., & Höög, C.
- Venue
- Science
- Published
- 2002-05-10
- Volume
- 296
- Issue
- 5570
- Pages
- 1115-1118
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1639816383
- Cited by
- 341
- References
- 1
- FWCI
- 21.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuan, L., Liu, J.-G., Hoja, M.-R., Wilbertz, J., Nordqvist, K., & Höög, C. (2002). Female Germ Cell Aneuploidy and Embryo Death in Mice Lacking the Meiosis-Specific Protein SCP3. Science. https://doi.org/10.1126/science.1070594
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