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Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry
Abstract
Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network in area CA3 or directly from the entorhinal cortex. To determine whether direct entorhinal connections support spatial firing and spatial memory, we removed all input from areas CA3 to CA1, thus isolating the CA1 area. Pyramidal cells in the isolated CA1 area developed sharp and stable place fields. Rats with an isolated CA1 area showed normal acquisition of an associative hippocampal-dependent spatial recognition task. Spatial recall was impaired. These results suggest that the hippocampus contains two functionally separable memory circuits: The direct entorhinal-CA1 system is sufficient for recollection-based recognition memory, but recall depends on intact CA3-CA1 connectivity.
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“Moreover, the disynaptic circuit can account for the residual hippocampal-dependent memory and high levels of CA1 place cell firing in vivo following surgical or genetic lesions of CA3 (Brun et al., 2002; Nakashiba et al., 2008).”
From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Brun et al., 2002
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Sorted by citations
Place Cells, Grid Cells, and the Brain's Spatial Representation System
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Metadata
- Authors
- Brun, V. H., Otnæss, M. K., Molden, S., Steffenach, H.-A., Witter, M. P., Moser, M.-B., & Moser, E. I.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Moser, Edvard I.
- Venue
- Science
- Published
- 2002-06-21
- Volume
- 296
- Issue
- 5576
- Pages
- 2243-2246
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004974848
- Cited by
- 606
- References
- 24
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 26 · 2020: 20 · 2019: 18 · 2018: 18 · 2017: 26 · 2016: 35 · 2015: 39 · 2014: 33 · 2013: 25 · 2012: 31
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- place cells, entorhinal cortex, hippocampal CA1, spatial memory, recollection
- MeSH terms
- Action Potentials, Animals, Brain Mapping, Denervation, Electrodes, Implanted, Hippocampus, Interneurons, Memory, Nerve Net, Neural Pathways, Mental Recall, Space Perception, Pyramidal Cells, Entorhinal Cortex, Maze Learning, Rats
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