The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides
Abstract
We have discovered two receptors for two different guests from a single dynamic combinatorial library. Each of the two guests amplifies the formation of a tightly binding host at the expense of unfit library members. Small differences in host-guest binding translate into useful differences in amplification. The selected hosts could be readily synthesized using biased dynamic libraries that contain only the right ratio of those building blocks that were selected by the guests. These results establish dynamic combinatorial chemistry as a practical method not only for the discovery but also for the synthesis of new receptors.
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Ma, J. C., & Dougherty, D. A. (1997) · Chemical Reviews · doi:10.1021/cr9603744 · Cited by 3,477
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
Dougherty, D. A. (1996) · Science · doi:10.1126/science.271.5246.163 · Cited by 2,656
Rowan, S. J., Cantrill, S. J., Cousins, G. R. L., Sanders, J. K. M., & Stoddart, J. F. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020315)41:6<898::aid-anie898>3.0.co;2-e · Cited by 2,588
Self-citationRuhland, K. (2020) · Catalysis from A to Z · doi:10.1002/9783527809080.cataz06077 · Cited by 1,724
Huc, I., & Lehn, J.-M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2106 · Cited by 460
Dynamic Combinatorial Chemistry
Lehn, J.-M., & Eliseev, A. V. (2001) · Science · doi:10.1126/science.1060066 · Cited by 403
Kearney, P. C., Mizoue, L. S., Kumpf, R. A., Forman, J. E., McCurdy, A., & Dougherty, D. A. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00075a006 · Cited by 277
Dynamic Combinatorial Libraries of Macrocyclic Disulfides in Water
Otto, S., Furlan, R. L. E., & Sanders, J. K. M. (2000) · Journal of the American Chemical Society · doi:10.1021/ja005507o · Cited by 268
Self-citationDynamic combinatorial chemistry
Otto, S., Furlan, R. L. E., & Sanders, J. K. M. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02086-4 · Cited by 167
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Dynamic Combinatorial Chemistry
Corbett, P. T., Leclaire, J., Vial, L., West, K. R., Wietor, J.-L., Sanders, J. K. M., & Otto, S. (2006) · Chemical Reviews · doi:10.1021/cr020452p · Cited by 1,922
Self-citationPrebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Herrmann, A. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60336a · Cited by 351
Azcune, I., & Odriozola, I. (2016) · European Polymer Journal · doi:10.1016/j.eurpolymj.2016.09.023 · Cited by 339
Chemically Fueled Self‐Assembly in Biology and Chemistry
Das, K., Gabrielli, L., & Prins, L. J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202100274 · Cited by 336
Metadata
- Authors
- Otto, S., Furlan, R. L. E., & Sanders, J. K. M.
- Venue
- Science
- Published
- 2002-07-26
- Volume
- 297
- Issue
- 5581
- Pages
- 590-593
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033344693
- Cited by
- 386
- References
- 9
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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