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Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly
Open accessAbstract
Molecular and supramolecular diversity may be generated, respectively, by reversible, covalent or noncovalent self-assembly of basic components whose various potential combinations in number and nature represent a virtual combinatorial library. This concept is applied to the induction of inhibitors of carbonic anhydrase (CA) by reversible recombination of aldehyde and amine components. It is found that the presence of CA favors the formation of those condensation compounds that may be expected to present the strongest binding to the CA active site. The virtual combinatorial library approach may represent a powerful methodology for the discovery of substrates, inhibitors, receptors, catalysts, and carriers for a variety of processes.
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Cites
Development and plasticity of cortical processing architectures
Singer, W. (1995) · Science · doi:10.1126/science.270.5237.758 · Cited by 669
Cited by
Dynamic Combinatorial Chemistry
Corbett, P. T., Leclaire, J., Vial, L., West, K. R., Wietor, J.-L., Sanders, J. K. M., & Otto, S. (2006) · Chemical Reviews · doi:10.1021/cr020452p · Cited by 1,922
Site-directed ligand discovery
Erlanson, D. A., Braisted, A. C., Raphael, D. R., Randal, M., Stroud, R. M., Gordon, E. M., & Wells, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9367 · Cited by 466
Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides
Otto, S., Furlan, R. L. E., & Sanders, J. K. M. (2002) · Science · doi:10.1126/science.1072361 · Cited by 386
Tethering: Fragment-Based Drug Discovery
Erlanson, D. A., Wells, J. A., & Braisted, A. C. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.33.110502.140409 · Cited by 385
Herrmann, A. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60336a · Cited by 351
Metadata
- Authors
- Huc, I., & Lehn, J.-M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-03-18
- Volume
- 94
- Issue
- 6
- Pages
- 2106-2110
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065633704
- Cited by
- 460
- References
- 1
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Huc, I., & Lehn, J.-M. (1997). Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.6.2106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
