The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet
Abstract
Insulin secretion from intact mouse pancreatic islets was investigated with two-photon excitation imaging. Insulin granule exocytosis occurred mainly toward the interstitial space, away from blood vessels. The fusion pore was unusually stable with a lifetime of 1.8 seconds. Opening of the 1.4-nanometer-diameter pore was preceded by unrestricted lateral diffusion of lipids along the inner wall of the pore, supporting the idea that this structure is composed of membrane lipids. When the pore dilated to 12 nanometers, the granules rapidly flattened and discharged their contents. Thus, our methodology reveals fusion pore dynamics in intact tissues at nanometer resolution.
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Chanturiya, A., Chernomordik, L. V., & Zimmerberg, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14423 · Cited by 201
Cited by
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Insulin granule dynamics in pancreatic beta cells
Rorsman, P., & Renstr�m, E. (2003) · Diabetologia · doi:10.1007/s00125-003-1153-1 · Cited by 844
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Protein-Lipid Interplay in Fusion and Fission of Biological Membranes
Chernomordik, L. V., & Kozlov, M. M. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161504 · Cited by 782
Matsuda, N., Lu, H., Fukata, Y., Noritake, J., Gao, H., Mukherjee, S., Nemoto, T., Fukata, M., & Poo, M.-M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1863-09.2009 · Cited by 260
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Metadata
- Authors
- Takahashi, N., Kishimoto, T., Nemoto, T., Kadowaki, T., & Kasai, H.
- Venue
- Science
- Published
- 2002-08-23
- Volume
- 297
- Issue
- 5585
- Pages
- 1349-1352
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092327340
- Cited by
- 267
- References
- 1
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Takahashi, N., Kishimoto, T., Nemoto, T., Kadowaki, T., & Kasai, H. (2002). Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet. Science. https://doi.org/10.1126/science.1073806
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
