The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Instruction of Translating Ribosome by Nascent Peptide
Abstract
Expression of the tryptophanase operon of Escherichia coli is regulated by catabolite repression and tryptophan-induced transcription antitermination. An induction site activated by l -tryptophan is created in the translating ribosome during synthesis of TnaC, the 24-residue leader peptide. Replacing the tnaC stop codon with a tryptophan codon allows tryptophan-charged tryptophan transfer RNA to substitute for tryptophan as inducer. This suggests that the ribosomal A site occupied by the tryptophanyl moiety of the charged transfer RNA is the site of induction. The location of tryptophan-12 of nascent TnaC in the peptide exit tunnel was crucial for induction. These results show that a nascent peptide sequence can influence translation continuation and termination within a translating ribosome.
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Structure of the 30S ribosomal subunit
Wimberly, B. T., Brodersen, D. E., Clemons, W. M., Morgan-Warren, R. J., Carter, A. P., Vonrhein, C., Hartsch, T., & Ramakrishnan, V. (2000) · Nature · doi:10.1038/35030006 · Cited by 2,035
Crystal structure of the ribosome at 5.5 Å resolution
Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H. D., & Noller, H. F. (2001) · Science · doi:10.1126/science.1060089 · Cited by 1,944
Upstream Open Reading Frames as Regulators of mRNA Translation
Morris, D. R., & Geballe, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8635-8642.2000 · Cited by 736
Cited by
The bacterial ribosome as a target for antibiotics
Poehlsgaard, J., & Douthwaite, S. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1265 · Cited by 607
Kramer, G., Boehringer, D., Ban, N., & Bukau, B. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1614 · Cited by 477
The Geometry of the Ribosomal Polypeptide Exit Tunnel
Voss, N. R., Gerstein, M., Steitz, T. A., & Moore, P. B. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.05.023 · Cited by 301
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
Seidelt, B., Innis, C. A., Wilson, D. N., Gartmann, M., Armache, J.-P., Villa, E., Trabuco, L. G., Becker, T., Mielke, T., Schulten, K., et al. (2009) · Science · doi:10.1126/science.1177662 · Cited by 276
Molecular Mechanism of Drug-Dependent Ribosome Stalling
Vazquez-Laslop, N., Thum, C., & Mankin, A. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.026 · Cited by 260
Metadata
- Authors
- Gong, F., & Yanofsky, C.
- Venue
- Science
- Published
- 2002-09-13
- Volume
- 297
- Issue
- 5588
- Pages
- 1864-1867
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1653006923
- Cited by
- 233
- References
- 3
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
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