The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
Open accessAbstract
Nascent Chains Revealed: Detailed analysis of protein translation and translocation across membranes requires the identification and structural analysis of intermediates involved in these processes (see the Perspective by Kampmann and Blobel ). Seidelt et al. (p. 1412 , published online 29 October) report the visualization by cryo-electron microscopy of a nascent polypeptide chain in the tunnel of the ribosome at 5.8 angstroms. This resolution allows analysis of the conformation and distinct contacts of the nascent chain within the ribosomal tunnel, which suggests a mechanism by which translational stalling is induced by this peptide. Protein translocation across cellular membranes involves the Sec61 protein, a component of a protein-conducting channel. Whether Sec61 acts as a monomer or as an oligomer during protein translocation has been unclear. Becker et al. (p. 1369 , published online 29 October) describe active yeast and mammalian ribosome-Sec61 structures that show the Sec61 complex interacting with the ribosome and a nascent secretory protein signal sequence. The analysis unambiguously reveals that the active protein-conducting channel is a single Sec61 copy with its central pore serving as conduit for the nascent polypeptide.
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Cites
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
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Self-citationFlexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics
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Self-citationThe Ribosomal Exit Tunnel Functions as a Discriminating Gate
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Self-citationElectrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates
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Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
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Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
Bai, X.-C., Fernandez, I. S., McMullan, G., & Scheres, S. H. (2013) · eLife · doi:10.7554/elife.00461 · Cited by 431
Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM
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Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.
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Metadata
- Authors
- Seidelt, B., Innis, C. A., Wilson, D. N., Gartmann, M., Armache, J.-P., Villa, E., Trabuco, L. G., Becker, T., Mielke, T., Schulten, K., Steitz, T. A., & Beckmann, R.
- Venue
- Science
- Published
- 2009-12-04
- Volume
- 326
- Issue
- 5958
- Pages
- 1412-1415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979947584
- Cited by
- 276
- References
- 26
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- green
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