The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of Toxoplasma gondii Myosin A in Powering Parasite Gliding and Host Cell Invasion
Open accessAbstract
Obligate intracellular apicomplexan parasites rely on gliding motion powered by their actomyosin system to disperse throughout tissues and to penetrate host cells. Toxoplasma gondii myosin A has been implicated in this process, but direct proof has been lacking. We designed a genetic screen to generate a tetracycline-inducible transactivator system in T. gondii . The MyoA gene was disrupted in the presence of a second regulatable copy of MyoA . Conditional removal of this myosin caused severe impairment in host cell invasion and parasite spreading in cultured cells, and unambiguously established the pathogenic function of this motor in an animal model.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943
Cited by
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes
Sidik, S. M., Huet, D., Ganesan, S. M., Huynh, M.-H., Wang, T., Nasamu, A. S., Thiru, P., Saeij, J. P. J., Carruthers, V. B., Niles, J. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.019 · Cited by 804
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
Lourido, S., Shuman, J., Zhang, C., Shokat, K. M., Hui, R., & Sibley, L. D. (2010) · Nature · doi:10.1038/nature09022 · Cited by 342
Invasion and intracellular survival by protozoan parasites
David Sibley, L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00990.x · Cited by 254
An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii
Munera Lopez, J., Tengganu, I. F., Liu, J., Murray, J. M., Arias Padilla, L. F., Zhang, Y., Brown, P. T., Florens, L., & Hu, K. (2022) · PLOS Pathogens · doi:10.1371/journal.ppat.1010776 · Cited by 14
Metadata
- Authors
- Meissner, M., Schlüter, D., & Soldati, D.
- Venue
- Science
- Published
- 2002-10-25
- Volume
- 298
- Issue
- 5594
- Pages
- 837-840
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084281420
- Cited by
- 481
- References
- 1
- FWCI
- 13.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Meissner, M., Schlüter, D., & Soldati, D. (2002). Role of Toxoplasma gondii Myosin A in Powering Parasite Gliding and Host Cell Invasion. Science. https://doi.org/10.1126/science.1074553
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
