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On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro
Abstract
The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or γ-aminobutyric acid (GABA)–ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity.
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Cited by
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Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2
Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipilä, S., Payne, J. A., Minichiello, L., Saarma, M., & Kaila, K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5265-03.2004 · Cited by 515
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Metadata
- Authors
- Cohen, I., Navarro, V., Clemenceau, S., Baulac, M., & Miles, R.
- Venue
- Science
- Published
- 2002-11-15
- Volume
- 298
- Issue
- 5597
- Pages
- 1418-1421
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069586118
- Cited by
- 1,001
- References
- 0
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cohen, I., Navarro, V., Clemenceau, S., Baulac, M., & Miles, R. (2002). On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro. Science. https://doi.org/10.1126/science.1076510
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