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Cited by 967

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Immunity-Related Genes and Gene Families in Anopheles gambiae

Open access
Christophides, George K., Zdobnov, Evgeny, Barillas-Mury, Carolina, Birney, Ewan, Blandin, Stephanie, Blass, Claudia, Brey, Paul T., Collins, Frank H., Danielli, Alberto, Dimopoulos, George, Hetru, Charles, Hoa, Ngo T., Hoffmann, Jules A., Kanzok, Stefan M., Letunic, Ivica, Levashina, Elena A., Loukeris, Thanasis G., Lycett, Gareth, Meister, Stephan, Michel, Kristin, Moita, Luis F., Müller, Hans-Michael, Osta, Mike A., Paskewitz, Susan M., Reichhart, Jean-Marc, Rzhetsky, Andrey, Troxler, Laurent, Vernick, Kenneth D., Vlachou, Dina, Volz, Jennifer, von Mering, Christian, Xu, Jiannong, Zheng, Liangbiao, Bork, Peer, Kafatos, Fotis C.·2002·Science
DOI 10.1126/science.1077136
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Abstract

We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster . Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.

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Metadata

Authors
Christophides, G. K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., Brey, P. T., Collins, F. H., Danielli, A., Dimopoulos, G., Hetru, C., Hoa, N. T., Hoffmann, J. A., Kanzok, S. M., Letunic, I., Levashina, E. A., Loukeris, T. G., Lycett, G., Meister, S., Michel, K., Moita, L. F., Müller, H.-M., Osta, M. A., Paskewitz, S. M., Reichhart, J.-M., Rzhetsky, A., Troxler, L., Vernick, K. D., Vlachou, D., Volz, J., von Mering, C., Xu, J., Zheng, L., Bork, P., & Kafatos, F. C.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2002-10-04
Volume
298
Issue
5591
Pages
159-165
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1077136
OpenAlex
W2125912444
Cited by
967
References
2
FWCI
16.81
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Immunity-Related Genes and Gene Families in Anopheles gambiae. https://app.cochat.ai/papers/10.1126/science.1077136
The paper
Christophides, G. K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., Brey, P. T., Collins, F. H., Danielli, A., Dimopoulos, G., Hetru, C., Hoa, N. T., Hoffmann, J. A., Kanzok, S. M., Letunic, I., Levashina, E. A., Loukeris, T. G., Lycett, G., Meister, S., . . . Kafatos, F. C. (2002). Immunity-Related Genes and Gene Families in Anopheles gambiae. Science. https://doi.org/10.1126/science.1077136

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.