The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction
Abstract
Genetic studies of single gene mutations are re-vealing mechanisms and pathways that regulate longevity across distant species (1). One such mechanism is an alteration in histone deacetylase activity. Abolishing expression of the Rpd3 deacetylase (2) or increasing expression of the Sir2 deacetylase (1) increases life-span in yeast; Sir2 mediates increased nematode longevity as well (1). Caloric restriction is an intervention that increases life-span in mammals, insects, nema-todes, and yeast (1, 3). Although the molecular pathways underlying the response to caloric re-striction are yielding to genetic analysis in yeast (1), there is little information on how this re-sponse is regulated in metazoans. We investigat-
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster
Pletcher, S. D., Macdonald, S. J., Marguerie, R., Certa, U., Stearns, S. C., Goldstein, D. B., & Partridge, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00808-4 · Cited by 571
Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila
Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 505
Self-citationLife extension in Drosophila by feeding a drug
Kang, H.-L., Benzer, S., & Min, K.-T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022631999 · Cited by 295
Dietary Restriction in Long-Lived Dwarf Flies
Clancy, D. J., Gems, D., Hafen, E., Leevers, S. J., & Partridge, L. (2002) · Science · doi:10.1126/science.1069366 · Cited by 289
Modulation of Life-span by Histone Deacetylase Genes in Saccharomyces cerevisiae
Kim, S., Benguria, A., Lai, C.-Y., & Jazwinski, S. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3125 · Cited by 210
Model Organisms as a Guide to Mammalian Aging
Tissenbaum, H. A., & Guarente, L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00098-3 · Cited by 129
The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo
Mannervik, M., & Levine, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6797 · Cited by 113
Dorn, R., Heymann, S., Lindigkeit, R., & Reuter, G. (1986) · Chromosoma · doi:10.1007/bf00285820 · Cited by 62
Cited by
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Self-citationSuppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361
Self-citationThe plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
NAD + in aging, metabolism, and neurodegeneration
Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319
Metadata
- Authors
- Rogina, B., Helfand, S. L., & Frankel, S.
- Venue
- Science
- Published
- 2002-11-29
- Volume
- 298
- Issue
- 5599
- Pages
- 1745-1745
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085772485
- Cited by
- 276
- References
- 8
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction. https://app.cochat.ai/papers/10.1126/science.1078986
- The paper
- Rogina, B., Helfand, S. L., & Frankel, S. (2002). Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction. Science. https://doi.org/10.1126/science.1078986
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
