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Cited by 885

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ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

Zilberman, Daniel, Cao, Xiaofeng, Jacobsen, Steven E.·2003·Science
DOI 10.1126/science.1079695
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Abstract

Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena . We cloned ARGONAUTE4 ( AGO4 ) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN ( SUP ) gene. The ago4-1 mutant reactivated silent SUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition, ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1 . These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation.

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Crossref · 10.1126/science.1079695

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Research works printed but not linked: 21

  1. 10.1073/pnas.200217597 · DOI
  2. 10.1101/gad.1026102 · DOI
  3. 10.1126/science.1063051 · DOI
  4. 10.1016/S0960-9822(00)00862-9 · DOI
  5. 10.1126/science.1076466 · DOI
  6. 10.1126/science.1074973 · DOI
  7. 10.1016/S0092-8674(02)00941-8 · DOI
  8. 10.1016/S0092-8674(02)00909-1 · DOI
  9. 10.1016/S1097-2765(02)00440-9 · DOI
  10. 10.1126/science.277.5329.1100 · DOI
  11. 10.1016/S0960-9822(02)00925-9 · DOI
  12. 10.1126/science.1059745 · DOI
  13. 10.1038/nature731 · DOI
  14. 10.1016/S0968-0004(00)01641-8 · DOI
  15. 10.1016/S1097-2765(05)00090-0 · DOI
  16. X. Cao S. E. Jacobsen Proc. Natl. Acad. Sci. U.S.A. DOI/10.1073/pnas.162371599 (2002). · DOI
  17. 10.1093/emboj/cdf464 · DOI · Paper page
  18. 10.1101/gad.193701 · DOI
  19. 10.1016/S0960-9822(02)00976-4 · DOI
  20. 10.1016/S1360-1385(02)02355-5 · DOI
  21. 10.1101/gad.1048103 · DOI

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Metadata

Authors
Zilberman, D., Cao, X., & Jacobsen, S. E.
Affiliations
Department of Molecular, Cell, and Developmental Biology,
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2003-01-31
Volume
299
Issue
5607
Pages
716-719
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1079695
Cited by
885
References
0
Language
en

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