CoChat
Sign Up
Cited by 885

The DOI matches its Crossref record.

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

Zilberman, Daniel, Cao, Xiaofeng, Jacobsen, Steven E.·2003·Science
DOI 10.1126/science.1079695
Open this paper in CoChat — free account

Abstract

Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena . We cloned ARGONAUTE4 ( AGO4 ) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN ( SUP ) gene. The ago4-1 mutant reactivated silent SUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition, ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1 . These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.1079695

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 21

  1. 10.1073/pnas.200217597 · DOI
  2. 10.1101/gad.1026102 · DOI
  3. 10.1126/science.1063051 · DOI
  4. 10.1016/S0960-9822(00)00862-9 · DOI
  5. 10.1126/science.1076466 · DOI
  6. 10.1126/science.1074973 · DOI
  7. 10.1016/S0092-8674(02)00941-8 · DOI
  8. 10.1016/S0092-8674(02)00909-1 · DOI
  9. 10.1016/S1097-2765(02)00440-9 · DOI
  10. 10.1126/science.277.5329.1100 · DOI
  11. 10.1016/S0960-9822(02)00925-9 · DOI
  12. 10.1126/science.1059745 · DOI
  13. 10.1038/nature731 · DOI
  14. 10.1016/S0968-0004(00)01641-8 · DOI
  15. 10.1016/S1097-2765(05)00090-0 · DOI
  16. X. Cao S. E. Jacobsen Proc. Natl. Acad. Sci. U.S.A. DOI/10.1073/pnas.162371599 (2002). · DOI
  17. 10.1093/emboj/cdf464 · DOI · Paper page
  18. 10.1101/gad.193701 · DOI
  19. 10.1016/S0960-9822(02)00976-4 · DOI
  20. 10.1016/S1360-1385(02)02355-5 · DOI
  21. 10.1101/gad.1048103 · DOI

Cited by

Sorted by citations

Metadata

Authors
Zilberman, D., Cao, X., & Jacobsen, S. E.
Affiliations
Department of Molecular, Cell, and Developmental Biology,
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2003-01-31
Volume
299
Issue
5607
Pages
716-719
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1079695
Cited by
885
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review