PreprintCited by 120Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromosomal and Genetic Variations

Confining euchromatin/heterochromatin territory: jumonji crosses the line

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Tamaru, Hisashi·2010·Genes & Development

Abstract

Heterochromatin is typically highly condensed, gene-poor, and transcriptionally silent, whereas euchromatin is less condensed, gene-rich, and more accessible to transcription. Besides acting as a graveyard for selfish mobile DNA repeats, heterochromatin contributes to important biological functions, such as chromosome segregation during cell division. Multiple features of heterochromatin—including the presence or absence of specific histone modifications, DNA methylation, and small RNAs—have been implicated in distinguishing heterochromatin from euchromatin in various organisms. Cells malfunction if the genome fails to restrict repressive chromatin marks within heterochromatin domains. How euchromatin and heterochromatin territories are confined remains poorly understood. Recent studies from the fission yeast Schizosaccharomyces pombe, the flowering plant Arabidopsis thaliana, and the filamentous fungus Neurospora crassa have revealed a new role for Jumonji C (JmjC) domain-containing proteins in protecting euchromatin from heterochromatin marks.

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Authors
Tamaru, H.
Affiliations
Gregor Mendel Institute of Molecular Plant Biology (AT)
Corresponding author
Tamaru, Hisashi
Venue
Genes & Development
Published
2010-07-15
Volume
24
Issue
14
Pages
1465-1478
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2163949420
Cited by
118
References
160
Citations by year
2026: 5 · 2025: 3 · 2024: 12 · 2023: 17 · 2022: 11 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 9
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Austrian Science Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
heterochromatin, euchromatin, histone modifications, DNA methylation, small RNA, heterochromatinization, Schizosaccharomyces pombe, Arabidopsis thaliana, Neurospora crassa
MeSH terms
Animals, Heterochromatin, Humans, Neurospora crassa, Nuclear Proteins, Schizosaccharomyces, Arabidopsis, Protein Structure, Tertiary, Euchromatin

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