The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis
Abstract
Although it has been known for some time that olfactory receptors (ORs) reside in spermatozoa, the function of these ORs is unknown. Here, we identified, cloned, and functionally expressed a previously undescribed human testicular OR, hOR17-4. With the use of ratiofluorometric imaging, Ca 2+ signals were induced by a small subset of applied chemical stimuli, establishing the molecular receptive fields for the recombinantly expressed receptor in human embryonic kidney (HEK) 293 cells and the native receptor in human spermatozoa. Bourgeonal was a powerful agonist for both recombinant and native receptor types, as well as a strong chemoattractant in subsequent behavioral bioassays. In contrast, undecanal was a potent OR antagonist to bourgeonal and related compounds. Taken together, these results indicate that hOR17-4 functions in human sperm chemotaxis and may be a critical component of the fertilization process.
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Cites
Combinatorial Receptor Codes for Odors
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How the olfactory system makes sense of scents
Firestein, S. (2001) · Nature · doi:10.1038/35093026 · Cited by 1,263
A sperm ion channel required for sperm motility and male fertility
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The Complete Human Olfactory Subgenome
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Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library
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Expression of members of the putative olfactory receptor gene family in mammalian germ cells
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Self-citationThe olfactory receptor gene superfamily: data mining, classification, and nomenclature
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Self-citation
Cited by
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191
Control of Male Gametophyte Development
McCormick, S. (2004) · THE PLANT CELL ONLINE · doi:10.1105/tpc.016659 · Cited by 600
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
Strünker, T., Goodwin, N., Brenker, C., Kashikar, N. D., Weyand, I., Seifert, R., & Kaupp, U. B. (2011) · Nature · doi:10.1038/nature09769 · Cited by 573
Nature’s Chemical Signatures in Human Olfaction: A Foodborne Perspective for Future Biotechnology
Dunkel, A., Steinhaus, M., Kotthoff, M., Nowak, B., Krautwurst, D., Schieberle, P., & Hofmann, T. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309508 · Cited by 549
Sperm guidance in mammals — an unpaved road to the egg
Eisenbach, M., & Giojalas, L. C. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1893 · Cited by 507
Metadata
- Authors
- Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J. A., Wetzel, C. H., Zimmer, R. K., & Hatt, H.
- Venue
- Science
- Published
- 2003-03-28
- Volume
- 299
- Issue
- 5615
- Pages
- 2054-2058
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047458612
- Cited by
- 769
- References
- 13
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J. A., Wetzel, C. H., Zimmer, R. K., & Hatt, H. (2003). Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis. Science. https://doi.org/10.1126/science.1080376
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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