The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library
Open accessAbstract
The recognition of odorants by olfactory receptors represents the first stage in odor discrimination. Here, we report the generation of an expression library containing a large and diverse repertoire of mouse olfactory receptor sequences in the transmembrane II-VII region. From this library, 80 chimeric receptors were tested against 26 odorants after transfection into HEK-293 cells. Three receptors were identified to respond to micromolecular concentrations of carvone, (-) citronellal, and limonene, respectively. We also found that the mouse I7 receptor, unlike the rat I7 receptor, prefers heptanal instead of octanal, as a result of a single valine-to-isoleucine substitution. This finding represents the beginning of a molecular understanding of odorant recognition. The identification, on a large scale, of cognate receptor-odorant interactions should provide insight into olfactory coding mechanisms.
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Cites
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Combinatorial Receptor Codes for Odors
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A second class of chemosensory receptors in the olfactory epithelium
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Metadata
- Authors
- Krautwurst, D., Yau, K.-W., & Reed, R. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 95
- Issue
- 7
- Pages
- 917-926
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2013083006
- Cited by
- 606
- References
- 39
- FWCI
- 17.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Krautwurst, D., Yau, K.-W., & Reed, R. R. (1998). Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library. Cell. https://doi.org/10.1016/s0092-8674(00)81716-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
