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Rapid Actin Transport During Cell Protrusion
Abstract
Transformed rat fibroblasts expressing two variants of green fluorescent protein, each fused to β-actin, were used to study actin dynamics during cell protrusion. The recently developed FLAP (fluorescence localization after photobleaching) method permits the tracking of one fluorophore after localized photobleaching by using the other as a colocalized reference. Here, by visualizing the ratio of bleached to total molecules, we found that actin was delivered to protruding zones of the leading edge of the cell at speeds that exceeded 5 micrometers per second. Monte Carlo modeling confirmed that this flow cannot be explained by diffusion and may involve active transport.
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Citations
Cited by
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451
Alexandrova, A. Y., Arnold, K., Schaub, S., Vasiliev, J. M., Meister, J.-J., Bershadsky, A. D., & Verkhovsky, A. B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003234 · Cited by 275
Real time analysis of STAT3 nucleocytoplasmic shuttling
Pranada, A. L., Metz, S., Herrmann, A., Heinrich, P. C., & Müller-Newen, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312530200 · Cited by 140
Metadata
- Authors
- Zicha, D., Dobbie, I. M., Holt, M. R., Monypenny, J., Soong, D. Y. H., Gray, C., & Dunn, G. A.
- Venue
- Science
- Published
- 2003-04-04
- Volume
- 300
- Issue
- 5616
- Pages
- 142-145
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964678604
- Cited by
- 177
- References
- 0
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zicha, D., Dobbie, I. M., Holt, M. R., Monypenny, J., Soong, D. Y. H., Gray, C., & Dunn, G. A. (2003). Rapid Actin Transport During Cell Protrusion. Science. https://doi.org/10.1126/science.1082026
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
