The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis
Abstract
Vascular smooth muscle cell (SMC) proliferation and migration are important events in the development of atherosclerosis. The low-density lipoprotein receptor–related protein (LRP1) mediates suppression of SMC migration induced by platelet-derived growth factor (PDGF). Here we show that LRP1 forms a complex with the PDGF receptor (PDGFR). Inactivation of LRP1 in vascular SMCs of mice causes PDGFR overexpression and abnormal activation of PDGFR signaling, resulting in disruption of the elastic layer, SMC proliferation, aneurysm formation, and marked susceptibility to cholesterol-induced atherosclerosis. The development of these abnormalities was reduced by treatment with Gleevec, an inhibitor of PDGF signaling. Thus, LRP1 has a pivotal role in protecting vascular wall integrity and preventing atherosclerosis by controlling PDGFR activation.
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Rohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455
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Metadata
- Authors
- Boucher, P., Gotthardt, M., Li, W.-P., Anderson, R. G. W., & Herz, J.
- Venue
- Science
- Published
- 2003-04-11
- Volume
- 300
- Issue
- 5617
- Pages
- 329-332
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049806614
- Cited by
- 581
- References
- 1
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
