Insulin resistance and atherosclerosis

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Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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Banting lecture 1988. Role of insulin resistance in human disease.

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Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol

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Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

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Immunoassay of endogenous plasma insulin in man

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MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial

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The Metabolic Syndrome: Time for a Critical Appraisal

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Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

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Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

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Gene regulation and DNA damage in the ageing human brain

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Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults

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Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

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NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older

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Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,344 · see citing works

Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease: The Bezafibrate Infarction Prevention (BIP) Study

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Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients

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Mitochondrial transfer between cells can rescue aerobic respiration

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

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The Metabolic Syndrome and 11-Year Risk of Incident Cardiovascular Disease in the Atherosclerosis Risk in Communities Study

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A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators.

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Association of Hemoglobin A _1c with Cardiovascular Disease and Mortality in Adults: The European Prospective Investigation into Cancer in Norfolk

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Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.

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Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.

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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice

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Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland

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Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

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Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

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Insulin Sensitivity and Atherosclerosis

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PPARs: therapeutic targets for metabolic disease

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Metabolic Syndrome vs Framingham Risk Score for Prediction of Coronary Heart Disease, Stroke, and Type 2 Diabetes Mellitus

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MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B

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Genomic instability in laminopathy-based premature aging

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Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption

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Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

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LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis

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Effect of Muraglitazar on Death and Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus

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Saturated Fatty Acids Promote Endoplasmic Reticulum Stress and Liver Injury in Rats with Hepatic Steatosis

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Mitochondrial Integrity and Function in Atherogenesis

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A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA

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Tumor necrosis factor alpha: a key component of the obesity-diabetes link

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Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

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Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

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Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice

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Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

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Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention

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A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria

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PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

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Secondary Prevention of Cardiovascular Events With Long-Term Pravastatin in Patients With Diabetes or Impaired Fasting Glucose

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Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis

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Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice

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