The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
Abstract
The phosphorylation of heptahelical receptors by heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptor kinases (GRKs) is a universal regulatory mechanism that leads to desensitization of G protein signaling and to the activation of alternative signaling pathways.We determined the crystallographic structure of bovine GRK2 in complex with G protein β 1 γ 2 subunits.Our results show how the three domains of GRK2–the RGS (regulator of G protein signaling) homology, protein kinase, and pleckstrin homology domains–integrate their respective activities and recruit the enzyme to the cell membrane in an orientation that not only facilitates receptor phosphorylation, but also allows for the simultaneous inhibition of signaling by Gα and Gβγ subunits.
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Claing, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00023-5 · Cited by 519
Cited by
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
Lefkowitz, R. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.06.006 · Cited by 417
Self-citationRibas, C., Penela, P., Murga, C., Salcedo, A., García-Hoz, C., Jurado-Pueyo, M., Aymerich, I., & Mayor, F. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.019 · Cited by 408
Genome-Wide Analysis of Membrane Targeting by S. cerevisiae Pleckstrin Homology Domains
Yu, J. W., Mendrola, J. M., Audhya, A., Singh, S., Keleti, D., DeWald, D. B., Murray, D., Emr, S. D., & Lemmon, M. A. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00083-8 · Cited by 337
Pleckstrin homology (PH) domains and phosphoinositides
Lemmon, M. A. (2007) · Biochemical Society Symposium · doi:10.1042/bss0740081 · Cited by 298
Structural Evolution of the Protein Kinase–Like Superfamily
Scheeff, E. D., & Bourne, P. E. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010049 · Cited by 273
Metadata
- Authors
- Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J., & Tesmer, J. J. G.
- Venue
- Science
- Published
- 2003-05-23
- Volume
- 300
- Issue
- 5623
- Pages
- 1256-1262
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028125482
- Cited by
- 381
- References
- 1
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J., & Tesmer, J. J. G. (2003). Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ. Science. https://doi.org/10.1126/science.1082348
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
